Google Scholar | Citations: 16429| h-index: 32 | i10-index: 482
Hypertensive disorders in pregnancy: preeclampsia, eclampsia and HELLP syndrome
Imagem licenciada por Canva.com
PDF (Portuguese (Brazil))

Keywords

Pre-eclampsia
Eclampsia
HELLP syndrome

How to Cite

Hypertensive disorders in pregnancy: preeclampsia, eclampsia and HELLP syndrome. (2022). Electronic Journal Collection Health, 15(8), e10681. https://doi.org/10.25248/reas.e10681.2022

Copyright © | All rights reserved.

The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.

Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.

Total reproduction
It is expressly prohibited and must be authorized by the journal.

Abstract

Objective: To analyze the characteristics of preeclampsia (PE), eclampsia and HELLP syndrome. Bibliographic review: PE encompasses hypertension accompanied by one or more other features: proteinuria, dysfunction of other maternal organs and/or uteroplacental dysfunction, beginning after 20 weeks of gestation. Eclampsia is a process related to PE that can occur before delivery, during delivery and up to 6 weeks after delivery, and is characterized by seizures. HELLP syndrome has a perinatal mortality rate of up to 37% and is characterized by hemolysis, elevated liver enzymes, and thrombocytopenia. Final considerations: Worldwide, hypertensive disorders of pregnancy are one of the main causes of morbidity and mortality for mothers and their newborns, especially pre-eclampsia, eclampsia and HELLP syndrome. PE consists of arterial hypertension with proteinuria and/or edema of the hands or face, while eclampsia is an evolution of PE with neurological symptoms, that is, tonic-clonic seizures. HELLP syndrome is also a progression of preeclampsia that leads to increased liver enzymes and thrombocytopenia. In this sense, as they are pathologies with a potential risk of maternal-fetal mortality, due attention to the diagnosis is essential, providing rapid and adequate treatment in order to avoid unfavorable outcomes.

PDF (Portuguese (Brazil))

References

ABRAHAM C, KUSHELEVA N. Management of Pre-eclampsia and Eclampsia: A Simulation. Med Ed PORTAL. 2019; 15: 10832.

ARIGITA ML, MARTÍNEZ GSF. HELLP syndrome: controversies and prognosis. Hipertens Riesgo Vasc, 2020; 37(4): 147-151.

ALVES AKR, et al. The clinical profile and the therapeutic management of the HELLP syndrome: integrative review. RSD, 2021; 10(14): e450101422194.

BURTON GJ, et al. Pre-eclampsia: pathophysiology and clinical implications. BMJ, 2019; 366: l2381

COLAFELLA KMM, et al. Aspirin for the prevention and treatment of pre-eclampsia: A matter of COX-1 and/or COX-2 inhibition? Basic Clin Pharmacol Toxico, 2020; 127(2): 132-141.

DUHIG K, et al. Recent advances in the diagnosis and management of pre-eclampsia. F1000Res. 2018; 7: 242.

GARDIKIOTI A, et al. Molecular Advances in Preeclampsia and HELLP Syndrome. Int J Mol Sci, 2022; 23(7): 3851.

KAHHALE S, et al. Pré-eclampsia. Revista De Medicina, 2018; 97(2): 226-234.

KHEDAGI AM, et al. Hypertensive Disorders of Pregnancy. Cardiol Clin, 2021; 39(1): 77-90.

KREBS VA, et al. HELLP syndrome and maternal mortality: an integrative review. Brazilian journal of health review, 2021; 4(2): 6297-6311.

LAM MTC, DIERKING E. Intensive Care Unit issues in eclampsia and HELLP syndrome. Int J Crit Illn Inj Sci, 2017; 7(3): 136-141.

LEE K, et al. Pre-eclampsia: a Scoping Review of Risk Factors and Suggestions for Future Research Direction. Regen Eng Transl Med, 2022; 10: 1-13.

MANGOGNA A, et al. Overview of procalcitonin in pregnancy and in pre-eclampsia. Clin Exp Immunol. 2019; 198(1): 37-46.

PERAÇOLI JC, et al. Pre-eclampsia/Eclampsia. Rev Bras Ginecol Obstet, 2019; 41(5): 318-332.

PERES GM, et al. Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Applied in Portugal. J Cardiovasc Dev Dis. 2018; 5(1): 3.

PETCA A, et al. HELLP Syndrome-Holistic Insight into Pathophysiology. Medicina (Kaunas), 2022; 58(2): 326.

PHIPPS EA, et al. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol, 2019; 15(5): 275-289.

RASANEN J, et al. Maternal serum glycosylated fibronectin as a point-of-care biomarker for assessment of preeclampsia. Am J Obstet Gynecol, 2015; 212(1): 82. e1–9. 10.

RIMAITIS K, et al. Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre. Int J Environ Res Public Health, 2019; 16(1): 109.

SILVA RS, et al. Importância do conhecimento sobre sinais e sintomas da pré-eclâmpsia para implementação dos cuidados de Enfermagem. Revista Eletrônica Acervo Saúde, 2019; 11(15): e1425.

SINKEY RG, et al. Prevention, Diagnosis, and Management of Hypertensive Disorders of Pregnancy: a Comparison of International Guidelines. Curr Hypertens Rep. 2020; 22(9): 66.

SOARES CT, et al. Fatores de risco relacionados a pré-eclâmpsia: uma revisão integrativa da literatura. Revista Eletrônica Acervo Saúde, 2019; (20): e437.

STOJANOVSKA V, ZENCLUSSEN AC. Innate and Adaptive Immune Responses in HELLP Syndrome. Front Immunol. 2020; 11: 667.

TOWSEND R, et al. Prediction of pre-eclampsia: review of reviews. Ultrasound Obstet Gynecol. 2019; 54(1): 16-27.

VAUGHT A, et al. Acute Cardiac Effects of Severe Pre-Eclampsia. J Am Coll Cardiol, 2018; 72(1): 1–11.