Keywords
Child
Infant
COVID-19
SARS-CoV-2
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Abstract
Objective: To identify the scientific productions developed on the pathophysiology of COVID-19 in childhood. Bibliographic review: The number of confirmed cases of COVID-19 among children is small when compared to other age groups. Most cases among children remain asymptomatic. Children with COVID-19 have milder symptoms and fewer hospitalizations and life-threatening complications. Severe cases of the disease such as Multisystem Inflammatory Syndrome have been described in children. Understanding the viral invasion through its Spike protein to the ACE 2 epithelial cells and through the transmembrane serine protease 2 may explain the decrease in pediatric cases. This group has these proteins, also to understand the functioning of pediatric signs and symptoms. As for transmission, it was believed that children, due to their milder symptoms, contributed little to its proliferation, but there is currently evidence that they can spread the infection. Final considerations: Children are likely to have differences in their immune responses to the virus. By covering this population in new scientific research, it may be possible to increase the preparedness to face new mutations emerging from both SARS-CoV-2 and other viral pathologies, transcending new endemics and pandemics, preparing and protecting the future of this population.
References
ALSAIED T, et al. Review of cardiac involvement in multisystem inflammatory syndrome in children. Circulation, 2021; 143(1): 78-88.
BAI KMD, et al. Clinical Analysis of 25 COVID-19 Infections in Children. The Pediatric Infectious Disease Journal, 2020; 39(7): e100-e103.
BI Q, et al. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study. The Lancet Infectious Diseases, 2020; 20(8): 911-919.
BIGLARI HN, et al. Acute transverse myelitis of childhood due to novel coronavirus disease 2019: the first pediatric case report and review of literature. Iranian Journal of Child Neurology, 2021; 15(1): 107-112.
BRASIL. Manuais do Ministério da Saúde. Secretaria de Vigilância em Saúde. 2022. In: Boletim epidemiológico especial: COVID-19. Disponível em https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/boletins-epidemiologicos/covid-19/2022/boletim-epidemiologico-no-112-boletim-coe-coronavirus.pdf/view. Acessado em: 9 de julho de 2022.
CASTELLANOS E, et al. Epidemiología y manifestaciones clínicas de COVID-19 en niñe. Instituto Nacional de Salud de El Salvador, 2020; 4(3): 58-68.
CUI X, et al. A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19). Journal of Medical Virology, 2021; 93(2): 1057-1069.
THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC). Disease Control and Prevention. 2020. In: Information for healthcare providers about multisystem inflammatory syndrome in children (MIS-C). Disponível em www.cdc.gov/mis-c/hcp/. Acessado em 09 jul. 2022.
DESAI AD, et al. “Long-term complications of COVID-19.” American Journal of Physiology, 2022; 322(1): C1-C11.
DEBIASI L e DELANEY M. Symptomatic and asymptomatic viral shedding in pediatric patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): under the surface. JAMA Pediatric, 2021; 175(1): 16-18.
DONG Y, et al. Epidemiology of COVID-19 among children in China. Pediatrics, 2020; 145(6): 1-10.
EASTIN C e EASTIN T. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. The Journal of Emergency Medicine, 2020; 58(4): 712-713.
FREUDENBERG S, et al. “Pandemia COVID-19: o que aprendemos e o que esperar no futuro?.” Seminários em Medicina Nuclear, 2022; 52(1): 86-89.
GOLDMAN RD. Coronavirus disease 2019 in children: surprising findings in the midst of a global pandemic. College of Family Physicians of Canada, 2020; 66(5): 332-334.
GUPTA A, et al. Extrapulmonary manifestations of COVID-19. Nature Medicine, 2020; 26: 1017–1032.
HENDERSON LA, et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 and Hyper inflammation in Pediatric COVID-19: Version 2. Arthritis & Rheumatology, 2021; 73(4): 13-29.
HOFFMANN M, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 2020; 181(2): 271-280.
HOLANDA TN, et al. Intervenções fisioterapêuticas no manejo de pacientes pediátricos frente as complicações da COVID-19: revisão integrativa. Revista Eletrônica Acervo Saúde, 2022; 15(6): e10213.
KOPANJA S, et al. Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population. Pediatric Allergy and Immunology, 2022; 33(2): 1-10.
LADHANI SN, et al. COVID-19 in children: analysis of the first pandemic peak in England. Archives of Disease in Childhood., 2020; 105(12): 1180-1185.
LI F, et al. Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study. The Lancet. Infectious Diseases, 2021; 21(5): 617-628.
LOPES AB, et al. Síndrome Inflamatória Multissistêmica Pediátrica associada à Covid-19: revisão narrativa. Revista Eletrônica Acervo Científico, 2022; 42: e10436.
LÓPEZ-SAMPAIO A, et al. Síndrome de COVID-19 persistente. Una revisión narrativa. Revista Clínica Espanola, 2021; 222(4): 241-250.
MARTINS MA, et al. Atualização sobre infecção por SARS-CoV-2 em crianças. Revista de Pediatria e Saúde Infantil Internacional, 2021; 41(1): 56-64.
MUSTAFA NM e SELIM LA. Characterisation of COVID-19 pandemic in paediatric age group: a systematic review and meta-analysis. Journal of Clinical Virology, 2020; 128(104395): 1-10.
NIKOLOPOULOU GB e MALTEZOU HC. COVID-19 in Children: Where do we Stand?. Archives of Medical Research. 2022; 53(1): 1-8.
ORGANIZAÇÃO MUNDIAL DA SAÚDE (OMS). Painel da OMS sobre o coronavírus (COVID 19). 2022. Disponível em https://covid19.who.int/. Acessado em 9 jul. 2022.
PATEL NA. Pediatric COVID-19: Systematic review of the literature. American Journal of Otolaryngology, 2020; 41(102573): 1-9.
QI F, et al. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. Biochemical and Biophysical Research Communications, 2020; 526: 135–140.
RAJAPASKE NI e DIXIT RA. Infecções humanas e novas por coronavírus em crianças: uma revisão. Revista de Pediatria e Saúde Infantil Internacional, 2021; 41(1): 36-55.
ROYCHOUDHURY S, et al. Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives. International Journal of Environmental Research and Public Health, 2020; 17(24): 1-39.
SACCO K, et al. Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19. Nature Medicine, 2022; 28: 1050–1062.
SANTOS MS e ANDRIGHETTO SSMT. Síndrome Inflamatória Multissistêmica Pediátrica e Doença de Kawazaki: as diferenças e manifestações clínicas na Pediatria. Revista Eletrônica Acervo Médico, 2022; 2: e9740.
TORAIH EA, et al. Multisystem inflammatory syndrome in pediatric COVID-19 patients: a meta-analysis.
World Journal of Pediatrics, 2021; 17(2): 141-151.
WILLIAMS PH, et al. “SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings.” Pathology, 2020; 52(7): 801-808.
WOHLGEMUTH CS, et al. Manejo da fisioterapia no âmbito hospitalar no paciente pediátrico com COVID-19: relato de casos. Fisioterapia hospitalar no paciente pediátrico com COVID-19. Revista Paulista de Pediatria, 2021; 39(e202023): 1-7.
ZHANG C, et al. Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series. PLoS Medicine, 2020; 17(6): 1-15.
ZIMMERMANN PE e CURTIS NI. COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features. The Pediatric Infectious Disease Journal, 2020; 39(6): 469-477.