Keywords
Treatment
Mutations
Epidemiology
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Abstract
Objective: To analyze the advances and perspectives of the epidemiological, clinical and therapeutic aspects of Triple Negative Breast Cancer (CMTN). Methods: integrative literature review, between 2017-2021, from PubMed, SciELO and LILACS databases using descriptors in Portuguese, English and Spanish. A total of 801 articles were identified, and 366 articles were selected after applying exclusion criteria. After reading and critical analysis that lasted about 6 months, 35 articles were chosen for the sample universe of this review. Results: The current standard treatment for early CMTN is based on chemotherapies, poly (adp-ribose) polymerase (PARP) inhibitors. for women with BRCA1 mutation and recently immunotherapies. However, new innovative proposals have emerged, such as vaccines, novel biomarkers and antiangiogenic therapies that are still under development. The prevalence of the neoplastic type was higher in women aged less than 40 years; black race; with the presence of the Breast Cancer Gene (BRCA) BRCA1 mutation. Final considerations: It was found that although some studies bring proposals with relevant gains (>10 months) in overall survival (SG), it is still necessary to achieve new advances in clinical and therapeutic aspects in CMTN.
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