Keywords
Diet
Chronic disease
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To analyze the indications, efficacy and side effects of the use of oral Minoxidil. Methods: This is an Integrative Literature Review type research, based on data from the U.S. National Library of Medicine (PubMed), Portal Capes and Cochrane Library. From the active search with the Descriptors in Health Sciences (DeCS): “Therapeutics”, “Minoxidil” and “Oral Administration” articulated by the Boolean operator “AND”, 15 articles were used for the study. Results: Oral Minoxidil proved to be a great alternative for people who are intolerant to topical use or who do not like the sensation of this substance. The main uses that have been shown to be effective include the different types of alopecia: androgenetic, areata, traction, frontal fibrosing and lichen planopilaris, in addition to Moniletrix, telogen effluvium and loose anagen hair syndrome in female cases. In men, for androgenic alopecia, areata, cicatricial and telogen effluvium and loose anagen hair syndrome were highlighted. It was also observed that among the side effects caused by this medication, hypertrichosis, which is an increase in hair growth, can be highlighted. Final considerations: Low doses can be considered a safe therapeutic modality for healthy individuals, presenting as adverse reactions: dermatitis, pruritus, scalp desquamation, sodium and water retention and weight gain, but it rarely causes serious side effects.
References
BEACH RA. Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy. Dermatol Ther., 2018; 31(6): e12707.
BEACH RA, et al. Low-dose oral minoxidil for treating alopecia: A 3-year North American retrospective case series. J Am Acad Dermatol., 2021; 84(3): 761-763.
CRAIGLOW BG, OLAMIJU B. Combination oral minoxidil and spironolactone for the treatment of androgenetic alopecia in adolescent girls. J Am Acad Dermatol., 2021; 84(6): 1689-1691.
CRANWELL WC, SINCLAIR R. "Loose Anagen Hair Syndrome: Treatment with Systemic Minoxidil Characterised by Marked Hair Colour Change." Australasian Journal of Dermatology, 2018; 59(4): E286-287.
GOMES AKG, GOUVEIA FILHO PS. Alopecia androgenética: O uso do minoxidil e seus efeitos adversos. Research, Society and Development, 2021; 10(9).
JHA AK, et al. Efficacy and safety of very-low-dose oral minoxidil 1.25 mg in male androgenetic alopecia. J Am Acad Dermatol., 2020; 83(5): 1491-1493.
JIMENEZ-CAUHE J, et al. Safety of low-dose oral minoxidil treatment for hair loss. A systematic review and pooled-analysis of individual patient data. Dermatologic therapy, 2020; 33(6).
LEMES LR, et al. Topical and Oral Minoxidil for Hair Disorders in Pediatric Patients: What Do We Know so Far? Dermatologic Therapy, 2020; 33(6): E13950.
NEGRÃO RP. Benefícios do uso do minoxidil oral no tratamento da alopecia androgenética. BWS Journal. 2022;.5: 1-10.
PERERA E, SINCLAIR R. Treatment of chronic telogen effluvium with oral minoxidil: A retrospective study. F1000Research, 2017; 6.
PIRMEZ R, SALAS-CALLO MD. Very-low-dose oral minoxidil in male androgenetic alopecia: A study with quantitative trichoscopic documentation. Journal of the American Academy of Dermatology, 2020; 82(1): 21-22.
RAMOS PM. Minoxidil 1 mg oral versus minoxidil 5% tópico para tratamento da alopecia de padrão feminino: ensaio clínico randomizado. Tese de Doutorado em Fisiopatologia em Clínica Médica apresentada à Universidade Estadual Paulista. Botucatu-SP, 2019.
RAMOS PM, et al. Minoxidil Sulfotransferase Enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss. J Eur Acad Dermatol Venereol., 2021; 35(1): e24-e26.
RANDOLPH M, TOSTI A. Oral minoxidil treatment for hair loss: A review of efficacy and safety. Journal of the European Academy of Dermatology, 2021; 84 (3): 737-746.
SHARMA AN, et al. Low-dose oral minoxidil as treatment for non-scarring alopecia: a systematic review. International Journal of Dermatology, 2020; 59(8): 1013-1019.
SINCLAIR RD. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Int J Dermatol. 2018; 57(1): 104-109.
SOUSA LMM, et al. A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem. 2017; 17-26.
SUCHONWANIT P, et al. Minoxidil and its use in hair disorders: a review. Drug design, development and therapy, 2019; 1: 2777-2786.
THERIANOU A, et al. How safe is prescribing oral minoxidil in patients allergic to topical minoxidil? J Am Acad Dermatol. 2020; 86(2): 429-431.
VAHABI‐AMLASHI S, et al. A Randomized Clinical Trial on Therapeutic Effects of 0.25 mg Oral Minoxidil Tablets on Treatment of Female Pattern Hair Loss. Dermatologic Therapy, 2021; 34(6): E15131
VAÑÓ-GALVÁN S, et al. Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients. J Am Acad Dermatol. 2021; 84(6): 1644-1651.
VILLANI A, et al. Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose. Journal of the European Academy of Dermatology and Venereology, 2021: 35(7).
WAMBIER CG, et al. Combination Tofacitinib and Oral Minoxidil Treatment for Severe Alopecia Areata. Journal of the American Academy of Dermatology. 2021; 85(3): 743-45.
WIPF A, et al. The Rise of Transcutaneous Drug Delivery for the Management of Alopecia: A Review of Existing Literature and an Eye towards the Future. Journal of Cosmetic and Laser Therapy, 2019; 21(5): 247-254.
YANG X, THAI KE. Treatment of permanent chemotherapy-induced alopecia with low dose oral Minoxidil. Australas J Dermatol, 2016; 57(4).