Neurological manifestations and general aspects of Anderson-Fabry

Abstract

Objective: To identify the neurological manifestations present in Fabry Disease (FD), is to update the theme in the national literature. Bibliographic review: The resulting effect of deposition is generalized inflammation and vasculopathy, which can also affect the individual's central and peripheral nervous system. FD evolves with renal dysfunction, skin angiokeratoma, cardiomyopathy, cerebrovascular events and neurological disorders. The neurological manifestations of FD are summarized with emphasis on cerebral vasculopathy, cochlear nerve dysfunction, psychiatric and cognitive symptoms, autonomic dysfunction, and peripheral neuropathy. Enzyme replacement therapy provides more prominent effects when given early in life, which makes diagnosing FD as early as possible essential. Final considerations: FD is a rare pathology, but very underdiagnosed. It is a systemic disease, and it is extremely important to recognize neurological changes and other systems, which must be recognized by health professionals. Early diagnosis and effective treatment prevent injuries to various organs, improving patient survival.