Keywords
Chinese plant extracts
Metabolic syndrome
Metabolic syndrome X
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Abstract
Objective: To describe the dose-response effect of the therapeutic action of Chinese Phytotherapy as a complementary or isolated treatment in Metabolic Syndrome (MS). Methods: The literature search was performed in the MEDLINE/PubMed, Embase, Cochrane, BVS and ClinicalTrials.gov databases. Gray literature was searched on Google Scholar and Scopus. Methodological analysis and risk of bias were performed using the Cochrane Risk of Bias (RoB2) tool, and analysis of methodological limitations using the CASP Randomized Controlled Trial Standard Checklist. The analysis of qualitative evidence was performed using GRADE-CERqual. The protocol of this systematic review was registered in PROSPERO with CRD42021281682. Results: Nine randomized controlled trials, all peer-reviewed, were included in this review for qualitative synthesis. In 88,8% of the studies included Chinese Herbal Medicine demonstrated a beneficial effect in the control of MetS. As for the analysis of qualitative evidence, the studies showed moderate to low confidence. Final considerations: Traditional Chinese Phytotherapy can control MS when used in a complementary or isolated way. However, the mechanism of action of these herbal medicines still needs to be further investigated by large-scale clinical trials.
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