Google Scholar | Citations: 16429| h-index: 32 | i10-index: 482
The antibiotic susceptibility pattern of pathogens causing urinary tract infection in the in the pediatric population
PDF (Portuguese (Brazil))

Keywords

Urinary Tract Infections
Bacteriuria
Pediatrics
Microbial Sensitivity Tests
Drug Resistance
Microbial

How to Cite

The antibiotic susceptibility pattern of pathogens causing urinary tract infection in the in the pediatric population. (2023). Electronic Journal Collection Health, 23(3), e12475. https://doi.org/10.25248/reas.e12475.2023

Copyright © | All rights reserved.

The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.

Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.

Total reproduction
It is expressly prohibited and must be authorized by the journal.

Abstract

Objective: To identify the main pathogens involved in urinary tract infection (UTI) in pediatrics and to evaluate their sensitivity to antimicrobials used for the treatment of UTI. Bibliographic review: UTI is one of the most frequent infections in the pediatric population. Due to its relevance and its potential to lead to chronic renal alterations, especially in infants, its early diagnosis is fundamental for the reduction of these comorbidities. Antimicrobial therapy is usually started empirically before urine culture results are available. Taking into account that Escherichia coli is the main bacteria that causes UTI in pediatrics, despite the increasing rate of bacterial resistance, it still shows sensitivity to carbapenems, third-generation cephalosporins, fourth-generation cephalosporins and aminoglycosides. Final considerations: UTI is a pathology in which care should be given as soon as possible after the diagnosis is made, in order to avoid future damage. The use of urine culture for diagnosis is important in identifying which pathogen is involved in order to determine the most appropriate treatment, reducing the risk of urinary tract complications and bacterial resistance.

PDF (Portuguese (Brazil))

References

ALBERICI LMA, et al. First urinary tract infections in children: the role of the risk factors proposed by the Italian recommendations. Acta Pædiatr., 2019; 108: 544- 550.

ALMEIDA ACC. Colheita de urina não invasiva em crianças: Revisão sistemática da literatura. Tese de Doutorado - Instituto Politécnico de Viseu, Portugal, Viseu, fevereiro de 2018.

AMIM EK, et al. Incidence, risk factors and causative bacteria of urinary tract infections and their antimicrobial sensitivity patterns in toddlers and children: A report from two tertiary care hospitals. Saudi J Kidney Dis Transpl., 2020; 31(1): 200-208.

AMMENTI A, et al. Updated Italian recommendations for the diagnosis, treatment and follow-up of the first febrile urinary tract infection in young children. Acta Paediatr., 2020; 109: 236–247.

AUTORE G, et al. Clinical Outcome of Discordant Empirical Therapy and Risk Factors Associated to Treatment Failure in Children Hospitalized for Urinary Tract Infections. Children, 2022; 9: 128.

AUTORE G, et al. Management of Pediatric Urinary Tract Infections: A Delphi Study. Antibiotics, 2022; 11: 1122.

BELETE Y, et al. Bacterial Profile and Antibiotic Susceptibility Pattern Of Urinary Tract Infection Among Children Attending Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia. Infect Drug Resist., 2019; 12: 3575–3583.

BRÍGIDO HPC, et al. Perfil de resistência de agentes de infecção urinária em crianças internadas em um hospital de pediatria em Belém do Pará. Braz. J. Hea. Rev., 2020; 3(4): 9808-9818.

BRYCE A, et al. Comparison of risk factors for, and prevalence of, antibiotic resistance in contaminating and pathogenic urinary Escherichia coli in children in primary care: Prospective cohort study. J. Antimicrob. Chemother., 2018; 73: 1359–1367.

CHASTAIN DB, et al. Rethinking urinary antibiotic breakpoints: Analysis of urinary antibiotic concentrations to treat multidrug resistant organisms. BMC Res. Notes, 2018; 11: 497.

ESPOSITO S, et al. Antibiotic Resistance in Paediatric Febrile Urinary Tract Infections. J. Glob. Antimicrob. Resist., 2021.

GANESH R, et al. Epidemiology of urinary tract infection and antimicrobial resistance in a pediatric hospital in Nepal. BMC infectious diseases, 2019; 19(1): 420.

KAUFMAN J, et al. Urinary tract infections in children: an overview of diagnosis and management. BMJ Paediatrics Open, 2019; 3: e000487.

KUMAR V, et al. Clinico-Microbiological Profile and Clinical Predictor of Urinary Tract Infection in Children: A Single-Center Study from Himalayan Foothills. Cureus, 2023; 15(1): e33289.

MAJUMDER MI, et al. Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh. Antimicrobial Resistance & Infection Control., 2022; 11: 156.

MAHONY M, et al. Multidrug-resistant organisms in urinary tract infections in children. Pediatr. Nephrol., 2020; 35: 1563–1573.

NICOLLE LE, et al. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases, 2019; 68: 83-110.

OHANU ME, et al. Etiology and Antimicrobial Susceptibility Pattern of Uropathogens in Children and Adolescents in a Tertiary Hospital: Moving from the Known to the Unknown. Archives of Clinical Microbiology, 2021; 12(S1): 141.

ROBERTS KB e WALD ER. The diagnosis of UTI: colony count criteria revisited. Pediatrics, 2018; 141: e20173239.

SAMANCI S, et al. Antibiotic resistance in childhood urinary tract infections: A single-center experience. Turk Pediatri Ars., 2020; 55(4): 386–392.

SIMÕES e SILVA AC, et al. Urinary tract infection in pediatrics: an overview. Jornal de Pediatria, 2019; 96(S1): 65-79.

TAN JKW, et al. Primary care approach to urinary tract infection in children. Singapore Med J., 2021; 62(7): 326-332.

TULLUS K e SHAIKH N. Urinary tract infections in children. Lancet, 2020; 395: 1659–1668.

UHLMANN A, et al. Infecção do Trato Urinário em Pediatria – Existe consenso entre os consensos? – Atualização 2021. Sociedade Brasileira de Pediatria, 2021; 7.

ÜNSAL H, et al. Relationship between urinalysis findings and responsible pathogens in children with urinary tract infections. Journal of Pediatric Urology, 2019; 15(6): 606.e6.

VENUGOPAL P, et al. Clinicoetiological profile of urinary tract infectionin pediatric population in a teaching hospital in south India. Int J Contemp Pediatr., 2021; 8(12): 1958-1964.

WANG ME, et al. Clinical Response to Discordant Therapy in Third-Generation Cephalosporin-Resistant UTIs. Pediatrics, 2020; 145: e20191608.

WOO B, et al. Antibiotic Sensitivity Patterns in Children with Urinary Tract Infection: Retrospective Study Over 8 Years in a Single Center. Child Kidney Dis., 2019; 23: 22-28.

ZHAO F, et al. A systematic review and meta-analysis of antibiotic resistance patterns, and the correlation between biofilm formation with virulence factors in uropathogenic E. coli isolated from urinary tract infections. Microb. Pathog., 2020; 144: 104196.

ZHU B, et al. Clinical guidelines of UTIs in children: quality appraisal with AGREE II and recommendations analysis. BMJ Open, 2022; 12: e057736.

ZHU FH, et al. Risk factors for community acquired urinary tract infections caused by extended spectrum β-lactamase (ESBL) producing Escherichia coli in children: A case control study. Infect. Dis. 2019; 51: 802–809.