Keywords
Cardiovascular Diseases
Triglycerides
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Abstract
Objective: To evaluate the role of dietary carbohydrates in cardiovascular disease and the lipid marker triglyceride and its impact on cardiovascular outcomes. Methods: Integrative literature review, with a search in the PubMed and Virtual Health Library (VHL) databases, in the time interval from 2012 to 2022, using Health Sciences Descriptors (DeCS) and Medical Subject Headings (Mesh): triglycerides, carbohydrates and cardiovascular risk factors with the Boolean operator “AND”. The following guiding question was used: What is the influence of dietary carbohydrates on the triglyceride marker and what is its relationship with cardiovascular disease? Results: 10 articles that met the inclusion criteria were included in this analysis. Altogether, among the studies included in the review, a sample of 17,879 individuals aged between 18 and 75 years was obtained. The average BMI varied between 23 and 45 kg/m². Final considerations: Low-carbohydrate diets can be effective for weight loss and promote benefits in short-term cardiovascular risk markers, with an increase in HDL levels. However, when it comes to triglycerides, the results are controversial.
References
ABBASI F, et al. High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart disease risk. The American Journal of Cardiology, 2000; 85(1): 45–8.
BARBER TM, et al. The Low-Carbohydrate Diet: Short-Term Metabolic Efficacy Versus Longer-Term Limitations. Nutrients, 2021; 13(4): 1187.
BAZZANO LA, et al. Effects of Low-Carbohydrate and Low-Fat Diets. Annals of Internal Medicine, 2014; 161(5): 309.
BLESSO CN, et al. Effects of carbohydrate restriction and dietary cholesterol provided by eggs on clinical risk factors in metabolic syndrome. Journal of Clinical Lipidology, 2013; 7(5): 463–71.
CAPURSO C. Whole-Grain Intake in the Mediterranean Diet and a Low Protein to Carbohydrates Ratio Can Help to Reduce Mortality from Cardiovascular Disease, Slow Down the Progression of Aging, and to Improve Lifespan: A Review. Nutrients, 2021; 13(8): 2540.
DEHGHAN M, et al. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. The Lancet, 2017; 390(10107): 2050–62.
DONG T, et al. The effects of low-carbohydrate diets on cardiovascular risk factors: A meta-analysis. Cheungpasitporn W, editor. PLOS ONE, 2020; 15(1): e0225348.
FOSTER GD, et al. A randomized trial of a low-carbohydrate diet for obesity. The New England journal of medicine, 2003; 348(21): 2082–90.
HA K, et al. A moderate-carbohydrate diet with plant protein is inversely associated with cardiovascular risk factors: the Korea National Health and Nutrition Examination Survey 2013–2017. Nutrition Journal, 2020; 19(1): 84.
KLEMPFNER R, et al. Elevated Triglyceride Level Is Independently Associated with Increased All-Cause Mortality in Patients With Established Coronary Heart Disease. Circulation: Cardiovascular Quality and Outcomes, 2016; 9(2): 100– 8.
LEE KW e CHO MS. The traditional Korean dietary pattern is associated with decreased risk of metabolic syndrome: findings from the Korean National Health and Nutrition Examination Survey, 1998-2009. Journal of medicinal food, 2014; 17(1): 43-56.
LUDWIG DS, et al. The carbohydrate-insulin model: a physiological perspective on the obesity pandemic. The American Journal of Clinical Nutrition, 2021; 114(6).
MANSOOR N, et al. Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials. British Journal of Nutrition, 2016; 115(3): 466-79.
MARTÍNEZ-GONZÁLEZ MA, et al. Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial. The American Journal of Clinical Nutrition, 2020; 111(2): 291–306.
MELLEN PB, et al. Whole grain intake and cardiovascular disease: A meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 2008; 18(4): 283–90.
MIN HS, et al. Blood Triglycerides Levels and Dietary Carbohydrate Indices in Healthy Koreans. Journal of Preventive Medicine and Public Health, 2016; 49(3): 153–64.
NICHOLLS SJ e NELSON AJ. HDL and cardiovascular disease. Pathology, 2019; 51(2): 142-147.
OLIVEIRA GMM, et al. Estatística Cardiovascular – Brasil 2021. Arquivos Brasileiros Card, 2022; 118(1): 115–373.
PADOVANI RM, et al. Dietary reference intakes: aplicabilidade das tabelas em estudos nutricionais. Revista de Nutrição, 2006; 19: 741–60.
PRÉCOMA DB, et al. Atualização da Diretriz de Prevenção Cardiovascular da Sociedade Brasileira de Cardiologia – 2019, Arquivos Brasileiros de Cardiologia, 2019; 113(4): 787–891.
RICHTER CK, et al. Plant protein and animal proteins: do they differentially affect cardiovascular disease risk? Adv Nutr, 2015; 6(6): 712-28.
ROA-DÍAZ ZM, et al. Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials. BMC cardiovascular disorders, 2022; 22(1): 377.
ROTH GA, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update from the GBD 2019 Study. Journal of the American College of Cardiology, 2020; 76(25): 2982–3021.
SACKS FM, et al. Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity: The OmniCarb Randomized Clinical Trial. JAMA, 2014; 312(23): 2531–41.
SCHIAVO M, et al. Influência da dieta na concentração sérica de triglicerídeos. Jornal Brasileiro de Patologia e Medicina Laboratorial, 2003; 39: 283–8.
SHIH CW, et al. Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining the Factors Interacting with Treatment Success (DIETFITS) trial. The American Journal of Clinical Nutrition, 2019; 109(2): 433–41.
SIEVENPIPER JL. Low-carbohydrate diets and cardiometabolic health: the importance of carbohydrate quality over quantity. Nutrition Reviews, 2020; 78(1): 69–77.
SIMÃO A, et al. I Diretriz Brasileira de Prevenção Cardiovascular. Arquivos Brasileiros de Cardiologia, 2013; 101(6):1–63.
SIRI-TARINO PW, et al. Saturated fat, carbohydrate, and cardiovascular disease. Am J Cli Nutr, 2010; 91(3):502-9.
SMART NA, et al. Low-fat diets for acquired hypercholesterolaemia. The Cochrane database of systematic reviews, 2011; 2011(2):CD007957.
SOLIMAN, GA. Dietary fiber, atherosclerosis, and cardiovascular disease. Nutrients, 2019; 11(5):1155- 2019.
SONESTEDT E, et al. The Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants. PLOS ONE, 2015;10(4): e0126104.
SOUZA MT, et al. Revisão integrativa: o que é e como fazer? Einstein (São Paulo), 2010; 8(1): 102–6.
STERN L, et al. The Effects of Low-Carbohydrate versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized Trial. Annals of Internal Medicine, 2004; 140(10): 778.
VEGA-LÓPEZ S, et al. Relevance of the Glycemic Index and Glycemic Load for Body Weight, Diabetes, and Cardiovascular Disease, Nutrients, 2018; 10(10): 1361.
VOLEK JS, et al. An Isoenergetic Very Low Carbohydrate Diet Improves Serum HDL Cholesterol and Triacylglycerol Concentrations, the Total Cholesterol to HDL Cholesterol Ratio and Postprandial Lipemic Responses Compared with a Low Fat Diet in Normal Weight, Normolipidemic Women. The Journal of Nutrition, 2003; 133(9): 2756–61.
WALLSTRÖM P, et al. Dietary fiber and saturated fat intake associations with cardiovascular disease differ by sex in the Malmö Diet and Cancer Cohort: a prospective study. PloS one, 2012; 7(2): e31637.
World Health Organization. The Top 10 Causes of Death [Internet]. World Health Organization. 2020.
Disponível em: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Acessado em: 19 de outubro de 2022.
YANG Q, et al. The effects of low-fat, high-carbohydrate diets vs. low-carbohydrate, high-fat diets on weight, blood pressure, serum liquids and blood glucose: a systematic review and meta-analysis. European Journal of Clinical Nutrition, 2022; 76(1): 16-27.