Keywords
Cholecalciferol
Vitamin D Deficiency
Comorbidity
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Abstract
Objective: To determine the prevalence of hypovitaminosis D in patients with systemic lupus erythematous (SLE). Methods: Cross-sectional study realized from data collected between January and August 2019, through medical records of patients of both sexes, diagnosed with SLE and aged between 18 and 80 years and serum calcidiol (25(OH)D) dosage. Data were analyzed using descriptive statistics, t-test, ANOVA and chi-square (p<0.005). The study was approved by the Research Ethics Committee. Results: There was a predominance of females 96.43% in our sample with a mean age of 48 ± 13 years. Only 32% of patients had adequate 25(OH)D values; The average concentration of 25(OH)D was 26.06 ng/dL. Conclusion: A high prevalence of inadequate levels of serum vitamin D was found both in patients with SLE and in the healthy population. This fact is relevant due to the existence of a specific recommendation for a higher value of vitamin D for patients with SLE, higher than that of the general population, and due to the peculiarity, that they have of not being able to expose themselves to sunlight.
References
ADEL Y, et al. Impact of vitamin D level and supplementation on systemic lupus erythematosus patients during COVID-19 pandemic. Archives of rheumatology, 2022; 37(2): 288-299.
BARBOSA WS, et al. Lúpus eritematoso sistêmico bolhoso - diagnóstico diferencial com dermatite herpetiforme. AN Bras Dermatol, 2011; 86(4): 92-5.
BOGACZEWICZ J, et al. Prevalence of autoantibodies directed against 1,25(OH)2D3 in patients with systemic lupus erythematosus. Pol Merkur Lekarski, 2010; 28 (164): 103-7.
COAN FC e BITENCOURT RM. The use of vitamin D in autoimmune diseases. Revista Inova Saúde, 2019; 9(1): 12-33.
COSTI LR, et al. Mortalidade por lúpus eritematoso sistêmico no Brasil: avaliação de causas segundo banco de dados de saúde do governo. Rev Bras Reumatol, 2017; 57(6): 574-582.
DUPUIS ML, et al. The role of vitamin D in autoimmune diseases: could sex make the difference? Biol Sex Differ, 2021; 12(1): 1-12.
FERREIRA CES, et al. Consensus - reference ranges of vitamin D [25(OH)D] from the Brazilian medical societies. Brazilian Society of Clinical Pathology/Laboratory Medicine (SBPC/ML) and Brazilian Society of Endocrinology and Metabolism (SBEM). J Bras Patol Med Lab, 2017; 53(6): 377-381.
FRAGOSO TS, et al. Níveis séricos de 25-hidroxivitamina D3 e sua associação com parâmetros clínicos e laboratoriais em pacientes com lúpus eritematoso sistêmico. Rev Bras Reumatol, 2012; 52(1): 55-65.
GAIK MRCP e DING HUI JEN MRCP. Vitamin D status in a monocentric cohort of systemic lupus erythematosus (SLE) patients and correlations with clinical and immunological profile Ong Swee. Med J Malaysia, 2019; 74(6): 492-498.
GALINDO CV e VEIGA R K. Características clínicas e diagnósticas do lúpus eritematoso sistêmico: uma revisão. Revista Eletrônica de Farmácia, 2011; 7(4): 1-13.
GERGIANAKI I, et al. High Comorbidity Burden in Patients with SLE: Data from the Community-Based Lupus Registry of Crete. Journal of Clinical Medicine, 2021; 10: 1-16.
GONZÁLEZ LA e ALARCÓN GS. The evolving concept of SLE comorbidities. Expert Rev Clin Immunol, 2017; 13(8): 753-768.
HASSANALILOU T, et al. Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation. Auto Immun Highlights, 2017; 9(1): 1-10.
LIMA GL. Avaliação da suplementação de vitamina D em pacientes com lúpus eritematoso de início juvenil: estudo clínico, randomizado, duplo-cego, controlado por placebo. Tese de Doutorado (Doutorado em Processos Inflamatórios e Alérgicos) - Faculdade de Medicina da Universidade de São Paulo, São Paulo, 2015; 69p.
MAGRO R, et al. Suplementação de vitamina D no lúpus eritematoso sistêmico: relação com atividade da doença, fadiga e expressão gênica de assinatura do interferon. BMC reumatologia, 2021; 5(1): 53.
MENDES MM, et al. Status da vitamina D nos trópicos: a exposição solar é o principal determinante? Nutr Bull, 2018; 43:428-434.
MENDOZA-PINTO C, et al. Risk factors of vertebral fractures in women with systemic lupus erythematosus. Clin Rheumatol, 2009; 28(5): 579-85.
MENEZES AM, et al. The importance of maintaining vitamin D levels for the immune system. Research, Society and Development, 2021; 10(12): 1-7.
MEZA-MEZA MR, et al. Association of High Calcitriol Serum Levels and Its Hydroxylation Efficiency Ratio with Disease Risk in SLE Patients with Vitamin D Deficiency. Journal of immunology research, 2021; 2021: ID2808613.
MISKOVIC R, et al. Vitamin D Status in Patients with Systemic Lupus Erythematosus in Serbia: Correlation with Disease Activity and Clinical Manifestations. J Med Sci, 2015; 3(2): 256-261.
MOSCONI JE, et al. Lúpus Eritematoso Sistêmico, análise epidemiológica em Cidades do Oeste do Paraná. Revista Thêma et Scientia, 2020; 10(1): 157-167.
NAKASHIMA CA, et al. Incidence and clinical-laboratory aspects of systemic lupus erythematosus in a Southern brazilian city. Rev Bras Reumatol, 2011; 51(3): 231-9.
NASCIMENTO DZ, et al. Prevalência de hipovitaminose D após alteração dos valores de referência / Prevalence of vitamin D deficiency after change of reference values. Rev Assoc Méd Rio Grande do Sul, 2021; 65 (2): 1-5.
ROLIZOLA PMD, et al. Insuficiência de vitamina D e fatores associados: um estudo com idosos assistidos por serviços de atenção básica à saúde. Ciência & Saúde Coletiva, 2022; 27(2): 653-663.
SCHENEIDER L. Níveis de vitamina D e perfil de citocinas em pacientes com lúpus eritematoso sistêmico. Dissertação de Mestrado (Mestrado em Ciências Médicas) - Faculdade de Medicina da Universidade Federal do Rio Grande do Sul. Porto Alegre, 2014; 87p.
SELVARAJA M, et al. Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis. PLOS ONE 2019; 14(11): e0224707.
SILVA DC, et al. Effects of vitamin D supplementation for systemic lupus erythematosus: a literature review. Braz J of Develop, 2020; 6(9): 65530-65539.
SIMIONI JÁ et al. Acerca de lúpus, vitamina D e leucopenia. Rev. Bras. Reumatol, 2016; 56(3): 206-211.
SOUBHIA BC, et al. Anticoncepção na paciente com lúpus eritematoso sistêmico. Femina, 2015; 43(2): 77-82.
SOUZA VA, et al. Associação de hipovitaminose D com Lúpus Eritematoso Sistêmico e inflamação. Jornal Brasileiro de Nefrologia, 2014; 36(4): 430-436.
SOUZA RR, et al. Fatores influentes da qualidade de vida em pessoas com lúpus eritematoso sistêmico. Acta Paul Enferm, 2021; 34: eAPE01173.
TEIXEIRA TM e COSTA CL. Papel da vitamina D no lúpus eritematoso sistêmico. Rev Nutr, 2012; 25 (4): 531-538.
VILAR MJP, et al. Incidência de Lúpus eritematoso Sistêmico em Natal, RN – Brasil. Rev. Bras. Reumato, 2003; 43(6): 347-51.
ZANETTE VC, et al. Lúpus eritematoso sistêmico e terapia de reposição hormonal: atualização. Femina, 2014; 42(6): 255-260.