Abstract
Objective: To address and understand the diagnosis and treatment of Polycystic Ovary Syndrome. Literature Review: Polycystic Ovary Syndrome is the result of chronic anovulation accompanied by hyperandrogenism and, in some cases, the formation of ovarian cysts. Causes include genetic disorders, family history, intrauterine influence, and extrinsic factors. However, alterations in the ovarian cycle, such as increased gonadotropin production and the consequent release of luteinizing and follicle-stimulating hormones, are the main triggers for the symptomatic picture of the syndrome. The clinical characteristics of Polycystic Ovary Syndrome encompass a variable spectrum, with various manifestations such as acne, hirsutism, obesity, insulin resistance, oligomenorrhea, or amenorrhea, in addition to the presence of cysts in the ovaries. Lifestyle changes and medication for symptoms are the basis of treatment, requiring individualized diagnosis and management for effectiveness. Final considerations: It is important to understand the clinical and laboratory criteria for Polycystic Ovary Syndrome in order to obtain an effective, individualized diagnosis and treatment that brings better prognosis to adolescent and adult women with this condition.
References
ALVES MLS, et al. Síndrome de ovários policísticos (SOP), fisiopatologia e tratamento, uma revisão. Research, Society and Development, 2022; 11: 9.
BERNI TR, et al. Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes. J Clin Endocrinol Metab, 2018; 103(6): 2116-2125.
BRASIL. Ministério da Saúde. Protocolo clínico e diretrizes terapêuticas síndrome de ovários policísticos. Portaria Conjunta nº 6, 2019. Disponível em: https://bvsms.saude.gov.br/bvs/saudelegis/saes/2019/poc0006_11_07_2019.html. Acessado em: 15 de fevereiro de 2022.
FACCHINETTI F, et al. Expert opinion on inositols in the treatment of polycystic ovary syndrome and non-insulin-dependent diabetes mellitus: an additional aid for human reproduction and beyond. Espert Opin Drug Metab Toxicol, 2020; 16(3): 255-274.
FEBRASGO. Federação Brasileira das Associações de Ginecologia e Obstetrícia. Síndrome dos ovários policísticos. Série orientações e recomendações FEBRASGO, 2018a; 103p.
FEBRASGO. Federação Brasileira das Associações de Ginecologia e Obstetrícia Tratado de Ginecologia. Rio de Janeiro: Grupo GEN, 2018; 998 p.
FEBRASGO. Federação Brasileira das Associações de Ginecologia e Obstetrícia Tratado de Ginecologia. Rio de Janeiro: Grupo GEN, 2019; 1024 p.
FEBRASGO. Federação Brasileira das Associações de Ginecologia e Obstetrícia Tratado de Ginecologia. Rio de Janeiro: Grupo GEN, 2021; 2717 p.
GOLLNICK HPM e DRENO B. Pathophysiology and management of acne. Journal of the European Academy of Dermatology and Venereology, 2015; 29: 1–2.
GOMES PCA. Aspectos ultrassonográficos na síndrome dos ovários policísticos: novas recomendações. Brazilian Journal of Health Review, 2021; 4(2): 6525-6535.
GRATTAN DR e TISSIER PL. Hypothalamic Control of Prolactin Secretion, and the Multiple Reproductive Functions of Prolactin. Knobil and Neill's Physiology of Reproduction, 2015; 12(4): 469–526.
IBÁÑEZ L, et al. An International Consortium Update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence. Horm Res Paediatr., 2017; 88(6): 371-395.
IBÁÑEZ L, et al. Toward a Treatment Normalizing Ovulation Rate in Adolescent Girls With Polycystic Ovary Syndrome. Journal of the Endocrine Society, 2020; 4(5): 01-09.
MANIQUE MÊS e FERREIRA AMAP. Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management. Revista Brasileira de Ginecologia e Obstetrícia. 2022; 44(4): 425-433.
PEREIRA JM, et al. Síndrome do Ovário Policístico: Terapia medicamentosa com metformina e anticoncepcionais orais. Saúde & Ciência em Ação, 2015; 1: 26-42.
ROSA-E-SILVA AC. Conceito, epidemiologia e fisiopatologia aplicada à prática clínica. In: Síndrome dos ovários policísticos. São Paulo: Federação Brasileira das Associações de Ginecologia e Obstetrícia (Febrasgo); 2019; 1(9): 1-15.
ROSENFIELD RL e EHRMANN DA. The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocr Rev, 2016; 37(5): 467-520.
ROSENFIELD RL. Avaliação diagnóstica da síndrome dos ovários policísticos em adolescentes. UpToDate, Nov. 2020.
SADEGHI HM, et al. Polycystic Ovarian Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Recovery. Int. J. Mol, 2022; 23(2): 583.
SHAW N e ROSENFIELD RL. Definição, características clínicas e diagnóstico diferencial da síndrome dos ovários policísticos em adolescentes. UpToDate, 2022.
SILVA IST, et al. A associação da mudança no estilo de vida com a terapia farmacológica no tratamento da Síndrome dos Ovários Policísticos (SOP). Revista Eletrônica Acervo Saúde, 2020; 57: e3909.
TEED HJ, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Human Reproduction, 2018; 33(9): 1602-1618.
TRENT M e GORDON, C M. Diagnosis and Management of Polycystic Ovary Syndrome in Adolescents. Pediatrics, 2020; 145: 2.
WITCHEL SF, et al. O diagnóstico da síndrome dos ovários policísticos na adolescência. Horm Res Pediatra 2015; 83: 376-389.
YELA DA. Particularities of diagnosis and treatment of polycystic ovary syndrome in adolescence. In: FEBRASGO. Polycystic ovary syndrome. São Paulo, 2018; 2: 16-28.
