Keywords
Polymorphism
SNP
Type 2 Diabetes
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To compile scientific studies that describe potential relationships between polymorphisms in the ABCA1, ADRB3, and SH2B1 and DM2 genes. Methods: Systematic review according to the PRISMA model and PICO strategy, based on the guiding question: “Which polymorphisms in the ABCA1, ADRB3 and SH2B1 genes are related to type 2 diabetes mellitus?”. The articles were searched in the databases. PubMed and VHL, according to defined inclusion and exclusion criteria. 1266 articles were found, after analysis, only 15 entered definitively to compose the review. Results: The association between DM2 and polymorphisms in the ABCA1 or ADRB3 genes is diverse and depends on the type of study, the number of patients and the nationality of those involved. Although there is a discreet publication that deals with the investigation of the relationship of SNPs in the SH2B1 and ADRB3 genes with DM2. In the SH2B1 gene, two SNPs possibly associated with DM2 were investigated. Final considerations: The discovery of the mechanisms that guide the relationship between DM2 and the genes studied in this review, based on their polymorphisms, is promising. in DM2.
References
AL-EITAN LN, et al. Genetic Association of SH2B1 Gene Polymorphisms in Jordanian Arab Patients with Type 2 Diabetes Mellitus, Diabetes Metab Syndr Obes., 2020; 13: 1825-1834.
BRASIL. Diretrizes metodológicas: elaboração de revisão sistemática e metanálise de ensaios clínicos randomizados. 2012. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1254554. Acessado em: 13 de junho de 2023.
BRASIL. Diabetes Mellitus. Cadernos de Atenção Básica. 2006. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/diabetes_mellitus_cab16.pdf. Acessado em: 13 de junho de 2023.
CANTO GL, et al. Risco de viés em revisões sistemáticas: guia prático. Centro Brasileiro de Pesquisas Baseadas em Evidências – COBE UFSC, 2021.
CHEHADEH S, et al. Genetic Variants and Their Associations to Type 2 Diabetes Mellitus Complications in the United Arab Emirates, Frontiers in Endocrinology, 2021; 12: 751885.
DINIZ IG, et al. Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon, Genetics and Molecular Biology, 2022; 45(2).
DU W, et al. ABCA1 Variants rs1800977 (C69T) and rs9282541 (R230C) Are Associated with Susceptibility to Type 2 Diabetes, Public Health Genomics, 2020; 23(1–2): 20–25.
GHAFAR MTA, et al. Association of ABCA1 (C69T) gene polymorphism with dyslipidemia and type 2 diabetes among the Egyptian population, Meta Gene, 2020; 25: 100714.
GOLBERT A, et al. Diretrizes Sociedade Brasileira de Diabetes. nº01/2020, Editora Clannad, 2020.
HASAN MM, et al. Association of ATP binding cassette transporter 1 (ABCA 1) gene polymorphism with type 2 diabetes mellitus (T2DM) in Bangladeshi population, Gene, 2019; 688: 151–154.
HE Y, et al. Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles, Circ Res, 2020; 127(9): 1198-1210.
JACOBO-ALBAVERA L, et al. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. Int. j. Mol. Sci. (Online), 2021; 22(4): 1–30.
KIM DS, et al. High genetic risk scores for impaired insulin secretory capacity doubles the risk for type 2 diabetes in Asians and is exacerbated by Western-type diets, Diabetes/Metabolism Research and Reviews, 2018; 34(1).
LI C e FAN D. Association between the ABCA1 rs1800977 polymorphism and susceptibility to type 2 diabetes mellitus in a Chinese Han population. Biosci. Rep, 2018; 38(2).
LI Z, et al. Model of genetic and environmental factors associated with type 2 diabetes mellitus in a Chinese Han population, BMC Public Health, 2020; 20(1): 1024–1024.
MIRANDA-LORA AL, et al. Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study, Pediatr Diabetes, 2017; 18(8): 824–831.
OCHOA-GUZMÁM A, et al. R230C but not − 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels. Journal of Endocrinological Investigation, 2020; 43(8): 1061–1071.
RAJA C. Association of ATP-Binding Cassette Transporter A1 G1051A Polymorphism with Type 2 Diabetes, Lipids and Coronary Artery Disease in Tunisian Population. Current Research in Diabetes & Obesity Journal, 2019; 11(4).
VELAZQUEZ-ROMAN J, et al. Association of FTO, ABCA1, ADRB3, and PPARG variants with obesity, type 2 diabetes, and metabolic syndrome in a Northwest Mexican adult population, J Diabetes Complications, 2021; 35(11): 108025–108025.
YAN R, et al. Association between ABC family variants rs1800977, rs4149313, and rs1128503 and susceptibility to type 2 diabetes in a Chinese Han population. J Int Med Res, 2020; 48(8): 300060520941347–300060520941347.
YAMADA Y, et al. Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population, PloS One, 2021; 16(8).