Keywords
Obesity
Genetics
SNP
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Abstract
Objective: To investigate in the literature genetic variants related to biochemical parameters of obesity. Methods: This is a systematic review of the literature in the Pubmed and Scielo databases, following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search was carried out following the selection criteria. Original articles were selected that addressed the biochemical parameters of obesity and their possible relationship with genetic polymorphisms in the ADRB3, ABCA1 and NPC1 genes. Journals published in Portuguese, English or Spanish in the last 10 years were included in this review. Literature review articles, dissertations, book chapters, editorials and duplicates were excluded from the review. The entire article management process was carried out on the Mendeley platform in order to avoid errors. Results: It is inferred that the SNPs rs4994, rs9282541 and rs1805082 of the ADRB3, ABCA1 and NPC1 genes, respectively investigated, are strongly associated with biochemical parameters of obesity, however, ethnic disparities could be identified related to different components blood biochemistry and different population groups, associated with age, gender and different BMI classifications. Conclusion: It is important to elucidate the association of SNP with different ethnic groups, promoting the advance in scientific knowledge about obesity.
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