Keywords
Depression
Digestive System
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To describe the fundamental principles of the gut microbiota, its contribution to the gut-brain axis, and its possible role in the pathophysiology of depression. Literature review: The imbalance in the relationship between brain-intestine-microbiota can have consequences for the psychic functions of patients, impacting the prevalence of Major Depressive Disorder. Considering that there is a causal role of dysbiosis in the pathogenesis of psychiatric diseases, being able to alter the behavior of individuals. That's because the gut microbiome has the ability to affect brain function through the modulation of neurotransmitters, influencing brain functions. Final considerations: The pathogenesis of depression is multicausal and poorly understood, and it is of paramount importance that the positive impacts on the therapy and prevention of this disorder are further addressed. Further studies on the subject are needed due to the possibility of including a balanced diet, probiotics and lifestyle change, for better intestinal health, as a pillar of treatment of major depressive disorder.
References
AVERINA OV, et al. Bacterial Metabolites of Human Gut Microbiota Correlating with Depression. International Journal Of Molecular Sciences, 2020; 21(23): 9234.
BUTLER MI, et al. The Gut Microbiome and Mental Health: What Should We Tell Our Patients?: Le Microbiote Intestinal Et La Santé Mentale : Que Devrions-Nous Dire à Nos Patients?. Canadian Journal of Psychiatry, 2019; 64(11): 747-60.
CAPUCO A, et al. Current Perspectives on Gut Microbiome Dysbiosis and Depression. Advances In Therapy, [S.L.] Springer Science and Business Media LLC., 2020; 37(4): 1328-1346.
CHANG L, et al. Brain-gut-microbiota axis in depression: A historical overview and future directions. Brain Res Bull, 2022; 182:44-56.
CHEUNG S, et al. Systematic Review of Gut Microbiota and Major Depression. Front. Psychiatry, 2019; 10: 34.
CHUDZIK A, et al. Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: modulation of the brain gut microbiome axis. Biomolecules, 2021; 11(7): 1000.
DALGALARRONDO P. Psicopatologia e semiologia dos transtornos mentais [recurso eletrônico]. Porto Alegre: Artmed, 2019. 611-627p.
GENEROSO JS, et al. O papel do eixo microbiota-intestino-cérebro em distúrbios neuropsiquiátricos. Revista Brasileira de Psiquiatria, 2021; 43(3): 293-305.
LIANG S, et al. Recognizing Depression from the Microbiota⁻Gut⁻Brain Axis. Int J Mol Sci, 2018 ; 19(6): 1592.
LIMBANA T, et al. "Gut Microbiome and Depression: How Microbes Affect the Way We Think." Curēus (Palo Alto, CA), 2020; 12(8): E9966.
MEDEIROS CI e TÉRCIO PC. Repercussão Da Microbiota Intestinal Na Modulação Do Sistema Nervoso Central E Sua Relação Com Doenças Neurológicas. Revista Ciências Médicas E Biológicas, 2020; 19(2): 342.
MOHAJERI MH, et al. Relationship between the gut microbiome and brain function. Nutrition Reviews, 2018; 76(7): 481–496.
RADJABZADEH D, et al. Gut microbiome-wide association study of depressive symptoms. Nat Commun, 2022; 13: 7128.
RUTSCH A, et al. The Gut-Brain Axis: how microbiota and host inflammasome influence brain physiology and pathology. Frontiers In Immunology, [S.L.], 2020; 11(1): 1-24.
SILVA CB, et al. A influência da microbiota intestinal na modulação de doenças psiquiátricas. Revista Educação na Saúde, Anápolis,2019; 7(2): 166-172.
SOCAłA K, et al. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharmacological Research, [S.L.] Elsevier BV, 2021; 172: 105840.
SOUZEDO FB, et al. O eixo intestino-cérebro e sintomas depressivos: uma revisão sistemática dos ensaios clínicos randomizados com probióticos. J bras psiquiatr, 2020; 69(4): 269–76.
SUDA K e KAZUNORI M. How Microbes Affect Depression: Underlying Mechanisms via the Gut-Brain Axis and the Modulating Role of Probiotics. International Journal of Molecular Sciences, 2022; 23(3): 1172.
TRACEY LK, et al. O Papel da Microbiota Intestinal em Intervenções Dietéticas para Depressão e Ansiedade, Avanços em Nutrição, 2020; 11(4): 890–907.
TRZECIAK P e HERBET M. Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression. Nutrients, 2021; 13(3): 927.
WINTER G, et al. Gut microbiome and depression: what we know and what we need to know. Reviews In The Neurosciences, 2018; 29(6): 629-643.