Keywords
postmenopausal women
obesity
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Abstract
Objective: To investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS), obesity, and oxidative stress markers in postmenopausal obese women. Methods: A total of 28 female patients participated in this experimental study. The patients were divided into three groups based on their classification in the Apnea-Hypopnea Index (AHI): G1 (11 individuals) with AHI ≤ 5 and BMI ≥ 29.9 kg/m2; G2 (9 individuals) with 5 ≥ AHI ≤ 15 and BMI ≥ 29.9 kg/m2; G3 (8 individuals) with AHI ≥ 15 and BMI ≥ 29.9 kg/m2. The production of superoxide, nitrites, and nitrates in these patients was evaluated and correlated with the AHI. Results: No significant differences were observed among the groups regarding the production of oxidative stress markers. Additionally, no significant correlations were found between the production of superoxide and serum levels of nitrites/nitrates and the apnea-hypopnea index (AHI) (r = 0.161; p = 0.074 and r = -0.357; p = 0.385, respectively). Conclusion: In postmenopausal obese women, there is no correlation between the severity of obstructive sleep apnea hypopnea syndrome and the evaluated oxidative stress markers. It is possible that the presence of untreated comorbidities and the distribution of body fat exert a greater influence on the production of free radicals in this population.
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