Keywords
Pregnancy
Prevention
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Abstract
Objective: Analyze strategies for preventing neonatal morbidity and mortality after premature rupture of membranes between weeks 34-37 of gestation. Methods: The integrative review, conducted on PubMed Central, resulted in the selection of 15 articles after applying inclusion and exclusion criteria. Results: Two main approaches to prevent premature rupture of membranes were identified. Pharmacological intervention, especially the use of prophylactic antibiotics, proved to be significantly effective in reducing the risk of adverse neonatal and maternal outcomes compared to approaches without antibiotic intervention. The choice of antibiotic was influenced by factors such as prolongation of the latency period and the infectious agent, typically gram-negative bacteria. However, the safety of the mother and fetus should be considered, especially when using macrolides, associated with risks such as spontaneous abortion and malformations, but also with a reduction in maternal hospitalization time. Final considerations: Point to the need for more research to develop safer and more effective methods of prevention for premature rupture of membranes, either through randomized studies or additional investigations.
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