Keywords
Epstein-Barr Virus
Zika Virus
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: This study explored the relationship between Epstein-Barr virus (EBV) and the Zika Virus with Guillain-Barré Syndrome (GBS) through an integrative review. Methods: The research, conducted on PubMed, resulted in 58 articles, of which 12 were used as data sources. Results: Findings revealed a significant association between viral infections by EBV and Zika virus and the development of GBS, although there were divergences in the prevalence of GBS associated with these infections. Literature indicated that approximately 50% to 70% of GBS cases were linked to a recent EBV infection. The prevalence of Zika virus infection in GBS cases was considerably higher than expected, varying significantly among studies. Final considerations: There is an intimate relationship between the development of GBS and prior infections with EBV and Zika virus. However, the divergence in the prevalence of Guillain-Barré cases associated with these viruses emphasizes the need for further research to clarify estimates and better understand the impact of these infections, especially in tropical regions with a high incidence of arboviruses.
References
ANSAR V, VALADI N. Guillain-Barré Syndrome. Prim care, 2015; 42(2): 189-93.
ARRIAGA-NIETO L, et al. Predict the incidence of Guillain Barré Syndrome and arbovirus infection in Mexico, 2014-2019. PLOS Glob Public Health, 2022; 2(3): e0000137.
BAUTISTA LE. Zika virus infection and risk of Guillain-Barré syndrome: A meta-analysis. Journal of the Neurological Sciences, 2019; 403: 99-105.
CHENG H, et al. Clinical characteristics of Epstein-Barr virus infection in the pediatric nervous system, BMC Infect Dis., 2020; 20(1): 886.
DAVIES AJ, et al. Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies. Neurol Neuroimmunol Neuroinflamm, 2022; 10(1): e200047.
FOKKE C, et al. Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria: A journal of neurology, 2014; 137: 33-43.
IQBAL R, et al. Antecedent infections, recent developments and future directions in Guillain-Barré syndrome. Revista Eletrônica Narrative Review, 2023; 4: 117-124.
LEE GH, et al. Clinical significance of Epstein-Barr virus in the cerebrospinal fluid of immunocompetent patients. Clin Neurol Neurosurg, 2021; 202: 106507.
LEONHARD SE, et al. Diagnóstico y manejo del Síndrome de Guillain-Barré en diez pasos. Guía Basada en la evidencia, 2021; 81: 817-836b.
LEONHARD SE, et al. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci, 2021; 420: 117272a.
LEONHARD SE, et al. An International Perspective on Preceding Infections in Guillain-Barré Syndrome: The IGOS-1000 Cohort. Neurology, 2022; 99(12): e1299-e1313.
LIMA MES, et al. Guillain-Barre syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil. Acta Trop, 2019; 197: 105064.
LINDEN, VVD, et al. Síndrome de Guillain-Barré em crianças: estudo clínico, laboratorial e epidemiologico em 61 pacientes. Arquivos de Neuro-Psiquiatria, 2010; 68: 12-17.
ORANTES L, et al. Incidencia de síndrome de Guillain-Barré durante la oleada de zika del 2016 en un hospital de segundo nivel. Neurología, 2017; 32: 1-5.
PINTO-DÍAZ CA, et al. Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond: Autoimmunity Reviews, 2017; 16: 327-334.
SÁNCHEZ OA, et al. Characterization of adult patients with Guillain-Barré syndrome during the arboviral infection outbreaks in Honduras. J Neurol Sci, 2021; 427: 117551.
SIMON O, et al. Zika virus outbreak in New Caledonia and Guillain-Barré syndrome: a case-control study: Journal of NeuroVirology, 2018; 24: 362-368.
UNCINI A, et al. Clinical and nerve conduction features in Guillain-Barré syndrome associated with Zika virus infection in Cúcuta, Colombia. Eur J Neurol, 2018; 25(4): 644-650.
HAO Y, et al. Antecedent infections in Guillain-Barré syndrome: a single-center, prospective study. Annals of Clinical and Translational Neurology, 2019; 6(12): 2510-2517.
WONG Y, et al. Estimating the global burden of Epstein-Barr virus-related cancers. J Cancer Res Clin Oncol., 2022; 148(1): 31-46.