Keywords
phage therapy
antimicrobial peptides
organometallic compounds
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Abstract
Objective: Approach the global public health challenge and the alternatives that are being developed to combat antimicrobial resistance. Bibliographic review: Increasing antimicrobial resistance is a global public health challenge that is associated with a high number of annual deaths and threatens to overtake cancer as the leading cause of mortality by 2050. Still, the development of new antimicrobials faces significant obstacles including the high cost, market uncertainty and lack of interest from the pharmaceutical industry. Searching to attenuate this scenario, new antimicrobial alternatives are being developed and demonstrate promising results. Phage therapy uses bacteriophages to infect bacteria, antimicrobial peptides are amino acid molecules with direct or immunomodulatory action, and organometallic compounds are coordination networks of metals and organic ligands with antimicrobial properties. Final considerations: Each of the alternatives described in presents advantages and challenges, but they all offer hope in the development of new effective antimicrobials. Antimicrobial resistance represents a threat to global public health and requires the search for innovative solutions to ensure the continued success of modern medicine.
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