Keywords
Multiple trauma
Vascular diseases
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Abstract
Objective: The objective of the present study is to compare the use of different anticoagulants in the thromboprophylaxis of patients with trauma. Methods: A systematic review was conducted in MEDLINE (PubMed), Cochrane and Scopus, using only analytical or experimental observational studies from the last 10 years, following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and registered in the PROSPERO database. Results: 27 articles were included, mostly retrospective cohort studies, with trauma of an orthopedic or blunt nature, and with a higher percentage of male patients, with an average age between 40 and 60 years. The most commonly used anticoagulant was Low Molecular Weight Heparin (LMWH), and the main diagnostic method was ultrasound (USG). Finally, a better prognosis was observed with the use of HPBM when compared to other traditional medications. However, when compared to rivaroxaban, divergences were found between studies. Final considerations: In thromboprophylaxis there is a predominance of the use of heparins, and LMWH further reduces the incidence of VTE and DVT. DOACs have pharmacodynamic superiority and milder adverse effects and are thus considered good alternatives in thromboprophylaxis.
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