Keywords
Medicinal Plant
Stomach Disease
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Abstract
Objective: To investigate the gastroprotective activity of S. purpurea fruit juice (SFS). Methods: Aliquots of SFS were collected and analyzed using thin chromatography to study the phytochemical composition. The gastroprotective activity was achieved by the methods of acute induction of ulcers by HCl/ethanol and anti-inflammatory in mice and by absolute ethanol in rats with SFS at concentrations of 25; 50 and 100%. Stomach lesions were quantified by computerized planimetry and the results were expressed as mean ± standard error, with p< 0.05 and differences between groups determined by one-way analysis of variance and Tukey and Dunett T3 post-test with GraphPad software. Prism®. Results: The phytochemical composition of SFS showed flavonoids and cinnamic derivatives. In acute ulcer induction, it was possible to observe that SFS significantly reduced the injured area in the stomach in the models: HCl/ethanol by 95, 73 and 79%; anti-inflammatory in 41, 38 and 89%; and absolute ethanol at 44, 72 and 99%, for the respective concentrations of 25, 50 and 100%. Conclusion: S. purpurea juice presented flavonoids in its composition and relevant gastroprotective properties under the tested conditions.
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