Keywords
Vitamin D
Depression
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To analyze the main scientific articles in the medical literature on the influence of gut microbiota and vitamin D on depression. Methods: Integrative literature review through searches, in the last 5 years (2019 – 2024), carried out in the databases: Scielo, PubMed, Latin American and Caribbean Literature (LILACS) and MEDLINE indexed in the Virtual Health Library (VHL). The following Boolean operators were used: “gut microbiota” AND “depression”, “vitamin D” AND “depression” and “gut microbiota” AND “vitamin D”. Results: The final sample was 26, all from PubMed, 13 articles addressed gut microbiota and depression, 8 articles on gut microbiota and vitamin D and 5 articles on vitamin D and depression. Final considerations: The research analyzed highlighted the complex relationship between gut microbiota and vitamin D in depression. Understanding the mechanisms that exist in this relationship offers new strategies for treating this debilitating disorder beyond emotional symptoms.
References
AGGELETOPOULOU I, et al. 2023. Exploring the Role of Vitamin D and the Vitamin D Receptor in the Composition of the Gut Microbiota. Frontiers in Bioscience (Landmark Edition), 2023; 28(6): 116.
AKIMBEKOV I, et al. Vitamin D and the Host-Gut Microbiome: A Brief Overview, Acta Histochemica et Cytochemica, 2020; 53(3): 33–42.
BEUREL E, et al. The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron, 2020; 107(2): 234–56.
BELLERBA F, et al. The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies. Nutrients, 2021; 13(10): 3378.
CAI Y, et al. Gut-brain axis in depression: Crosstalk between neuroinflammation and gut microbiota. Advanced Neurology, 2023;1(3): 272.
CANTORNA MT, et al. Vitamin A and vitamin D regulate the microbial complexity, barrier function and the mucosal immune responses to insure intestinal homeostasis. Critical reviews in biochemistry and molecular biology, 2019; 54(2): 184–192.
CHATTERJEE I, et al. Vitamin D Receptor Promotes Healthy Microbial Metabolites and Microbiome. Scientific Reports, 2020; 10(1): 7340.
CROLL PH, et al. Associations of Vitamin D Deficiency with MRI Markers of Brain Health in a Community Sample, Clinical Nutrition, 2021; 40(1): 72–78.
CRUZ-PEREIRA JS, et al. Depression’s Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome. Annual Review of Psychology, 2020; 71(1): 49–78.
DUDEK KA, et al. Neurobiology of Resilience in Depression: Immune and Vascular Insights from Human and Animal Studies. The European Journal of Neuroscience, 2021; 53(1): 183–221.
GENG C, et al. Vitamin D and Depression: Mechanisms, Determination and Application, Asia Pacific Journal of Clinical Nutrition, 2019; 28(4): 689–694.
GÓRALCZYK-BIŃKOWSKA A, et al. The Microbiota-Gut-Brain Axis in Psychiatric Disorders. International Journal of Molecular Sciences, 2022; 23(19): 11245.
KOUBA BR, et al. Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety. International Journal of Molecular Sciences, 2022; 23(13): 7077.
MADAN A, et al. The Gut Microbiota Is Associated with Psychiatric Symptom Severity and Treatment Outcome among Individuals with Serious Mental Illness. Journal of Affective Disorders, 2020; 264: 98–106.
MAYNE PE e BURNE TH. Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness. Trends in Neurosciences, 2019; 42(4): 293–306.
MCGUINNESS AJ, et al. A Systematic Review of Gut Microbiota Composition in Observational Studies of Major Depressive Disorder, Bipolar Disorder and Schizophrenia. Molecular Psychiatry, 2022; 27(4): 1920–1935.
MUSAZADEH V, et al. Vitamin D Protects against Depression: Evidence from an Umbrella Meta-Analysis on Interventional and Observational Meta-Analyses. Pharmacological Research, 2023; 187: 106605.
OTAKA M, et al. Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota. Microorganisms, 2021; 9(5): 1026.
PORTO CM, et al. Contribuições da vitamina D no tratamento de sintomas depressivos e fatores de risco cardiovascular: protocolo de estudo para um ensaio clínico randomizado, duplo-cego e controlado por placebo. Trials, 2019; 20: 583.
RUTSCH A, et al. The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Frontiers in Immunology, 2020; 11: 604179.
SANADA K, et al. Gut Microbiota and Major Depressive Disorder: A Systematic Review and Meta-Analysis. Journal of Affective Disorders, 2020; 266: 1–13.
SHIEH A, et al. Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome? Journal of Clinical Endocrinology and Metabolic, 2021; 106(12): 3464–76.
SINGH P, et al. The Potential Role of Vitamin D Supplementation as a Gut Microbiota Modifier in Healthy Individuals. Scientific Reports, 2020; 10(1): 21641.
SMITH DG, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology, 2019; 236(5): 1653–70.
TANELIAN A, et al. Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns. Biology of Sex Differences, 2024; 15(1): 20.
TANGESTANI H, et al. Vitamin D and The Gut Microbiota: A Narrative Literature Review. Clinical Nutrition Research, 2021; 10(3): 181–191.