Keywords
Vaccination
COVID-19
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To gather and analyze evidence to understand and correlate the influence of Takotsubo syndrome (TTS) induced by Covid-19 vaccination. Methods: A integrative literature review including articles published between 2021 and 2024 and selected through access to scientific publication platforms such as Scielo, BVS, PubMed, and Elsevier. The descriptors Covid Vaccine and Takotsubo Syndrome were used. Articles belonging to the typology of editorials, expert opinions, responses to opinions, reviews, book chapters, and isolated case reports were excluded. Results: 13 articles were included, of which 12 articles found an association between Covid-19 vaccination and TTS. There is a higher incidence of this complication produced by messenger RNA (mRNA) vaccines compared to other vaccines. The most prevalent symptoms in TTS induced by vaccination include chest pain, fever, cough, dyspnea, nausea, and digestive symptoms. Electrocardiographic changes were evidenced (ST segment elevation and T wave inversion) as well as elevation of cardiac markers (troponin, CK-MB, and NT-proBNP). Imaging exams showed ground-glass opacities, pulmonary consolidation, and increased cardiac silhouette. Final considerations: It is crucial to monitor the effects of Covid-19 vaccines to develop effective prevention and management strategies
References
AL HOURI HN, et al. Pathophysiology of stress cardiomyopathy: A comprehensive literature review. Annals of medicine and surgery, 2012; 82: 104671.
ALMAS T, el al. Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022; 149: 112843.
BARBIERI L, et al. Takotsubo syndrome in COVID-19 era: Is psychological distress the key? Journal of Psychosomatic Research, 2021; 140: 110297.
DE LIMA DHL, et al. Como elaborar uma revisão integrativa: sistematização do método científico. Revista Recien-Revista Científica de Enfermagem, 2022; 12(37): 334-345.
DE SOUZA DAB, et al. Relação dos efeitos colaterais com os tipos de vacinas da COVID-19. Research, Society and Development, 2023; 2(12): 10121243849.
FAZLOLLAHI A, et al. Cardiac complications following mRNA COVID‐19 vaccines: a systematic review of case reports and case series. Reviews in medical virology, 2022; 32(4): 2318.
GHASEMI H, et al. Takotsubo syndrome and COVID-19: A systematic review. Health science reports, 2022; 6(1): 972.
HANA D, et al. Clinical cardiovascular adverse events reported post-COVID-19 vaccination: are they a real risk? Current Problems in Cardiology, 2022; 47(3): 101077.
HEGDE S, et al. Characteristics and outcome of patients with COVID-19 complicated by Takotsubo cardiomyopathy: case series with literature review. Open heart, 2020; 7(2): 001360.
HO JS, et al. A review of COVID-19 vaccination and the reported cardiac manifestations. Singapore medical journal, 2023; 64(9): 543-549.
KHALID AS, et al. Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis. International journal of cardiology. Heart & vasculature, 2022; 43: 101108.
LI C, et al. Takotsubo syndrome and vaccines: a systematic review. ESC Heart Failure, 2024.
LI P, et al. Vaccination-induced takotsubo syndrome: a systematic review. Journal of the American College of Cardiology, 2023; 81(8-Supplement): 575-575.
LI YE, et al. Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases, 2022; 124: 1–10.
MOADY G e ATAR S. Takotsubo Syndrome During the COVID-19 Pandemic: State-of-the-Art Review. CJC open, 2021; 3(10): 1249–1256.
OKURA H. Update of takotsubo syndrome in the era of COVID-19. Journal of cardiology, 2021; 77(4): 361–369.
PAKNAHAD MH, et al. Cardiovascular complications of COVID-19 vaccines: A review of case-report and case-series studies. Heart & lung: the journal of critical care, 2023; 59: 173–180.
POGRAN E, et al. Takotsubo syndrome before and during the COVID-19 pandemic in Austria: a retrospective cohort study (TOSCA-19). ESC heart failure, 2023; 10(6): 3667–3676.
ROSH B, et al. Trends in occurrence of takotsubo syndrome and association with SARS-CoV-2 infection and COVID-19 vaccination. Journal of Cardiovascular Medicine, 2023; 24(11): 815-821.
SHAH RM, et al. Takotsubo Syndrome and COVID-19: Associations and Implications. Current problems in cardiology, 2021; 46(3): 100763.
SINGH B, et al. A Systematic Review of COVID-19 Vaccine-Induced Takotsubo Cardiomyopathy: A 2023 Update. Cureus, 2023; 15(12): 50319.
TEDESCHI A, et al. Recent highlights on acute myocardial infarction and takotsubo syndrome from the International Journal of Cardiology: Heart & Vasculature. International Journal of Cardiology. Heart & Vasculature, 2022; 43.
WONG MK, et al. COVID-19 Mortality and Progress Toward Vaccinating Older Adults - World Health Organization, Worldwide, 2020-2022. MMWR. Morbidity and mortality weekly report, 2023; 72(5): 113–118.