Supplementary Files
Keywords
Human papillomavirus
Prevalence
Types of HPV
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Abstract
Objective: To estimate the prevalence and genotypic distribution of Human Papillomavirus (HPV) in penile cancer in Brazil. Methods: This is a systematic review and meta-analysis of studies published from 2000 to 2021, that investigated the prevalence and genotypic distribution of HPV in penile cancer in different geographical regions in Brazil, using molecular methods. The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), conducted in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis Statement (PRISMA) and the quality of included studies was assessed by the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Studies Reporting Prevalence Data. Results: 15 studies were included, comprising 1,250 cases. The combined prevalence of HPV in penile cancer was 52.0% and the highest prevalence was observed in the Northeast region (79%), followed by the North region (54%), Southeast (44%) and Central-West region (31%). HPV16 was the most prevalent genotype, followed by HPV6, HPV11, HPV18, HPV51, HPV59, HPV74, HPV31, HPV35 and HPV68. Final considerations: Our results confirm the association of HPV with penile cancer and highlight the presence of viral genotypes not covered by the tetravalent prophylactic vaccine distributed by the public health system in Brazil.
References
AFONSO LA, et al. Human papillomavirus, Epstein‐Barr virus, and methylation status of p16ink4a in penile cancer. Journal of Medical Virology, 2017; 89(10): 1837-1843.
AFONSO LA, et al. Prevalence of human papillomavirus and Epstein-Barr virus DNA in penile cancer cases from Brazil. Memórias do Instituto Oswaldo Cruz, 2012; 107: 18-23.
ANVISA. AGÊNCIA NACIONAL DE VIGILÂNCIA SANITÁRIA. 2017. Registrada vacina do HPV contra 9 subtipos do vírus. Disponível em: https ://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2017/registrada-vacina-do-hpv-contra-9-subtipos-do-virus. Accessed on: 2022.
ALEMANY L, et al. Role of human papillomavirus in penile carcinomas worldwide. European Urology, 2016; 69(5): 953-961.
ARAÚJO LA, et al. Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors. PloS One, 2018; 13(6): 0199557.
BANDINI M, et al. A global approach to improving penile cancer care. Nature Review Urology. 2022; 19(4): 231-239.
BERRIDGE C and GODDARD J. Penile metastasis presenting as oedema: A case report and management approach. Urology Case Report. 2020; 5(31): 101166.
BEZERRA ALR, et al. Clinicopathologic features and human papillomavirus DNA prevalence of warty and squamous cell carcinoma of the penis. The American Journal of Surgical Pathology, 2001; 25(5): 673-678.
BEZERRA ALR, et al. Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. Cancer, 2001; 91(12): 2315-2321.
BRUNI L, et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report. 2023.
BUSSO-LOPES AF, et al. Genomic profiling of human penile carcinoma predicts worse prognosis and survival. Cancer Prevention Research. 2015; 8(2): 149-156.
CALMON MF, et al. Overexpression of ANXA1 in penile carcinomas positive for high-risk HPVs. PLoS One. 2013; 8(1): 53260.
CUBILLA AL, et al. The World Health Organization 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert-driven recommendations. Histopathology. 2016: 72(6): 893-904.
DE PEDER LD, et al. Association between human papillomavirus and non-cervical genital cancers in Brazil: a systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention: APJCP. 2018; 19(9): 2359.
FONSECA AG, et al. Human Papilloma Virus: Prevalence, distribution, and predictive value to lymphatic metastasis in penile carcinoma. International Brazilian Journal of Urology. 2013; (39): 542-550.
HELD-WARMKESSEL J. Penile cancer. Seminars in Oncology Nursing. WB Saunders, 2012; 190-201.
KORKES F, et al. Tendências e carga econômica do câncer de pênis no sistema público de saúde brasileiro. Einstein (São Paulo), 2020; 18:1-6.
KUASNE H, et al. Genome-wide methylation, and transcriptome analysis in penile carcinoma: uncovering new molecular markers. Clinical Epigenetics, 2015; 7(1): 1-10.
LAURENT JS, et al. HPV vaccination and the effects on rates of HPV-related cancers. Current Problems in Cancer, 2018; 42(5): 493-506.
MACEDO J, et al. Genomic profiling reveals the pivotal role of hrHPV driving copy number and gene expression alterations, including mRNA downregulation of TP53 and RB1 in penile cancer. Molecular Carcinogenesis, 2020; 59(6): 604-617.
MARTINS VA, et al. P16INK4a expression in patients with penile cancer. PloS One, 2020; 13(10): 0205350.
MARTINS VCA, et al. Presence of HPV with overexpression of p16INK4a protein and EBV infection in penile cancer - A series of cases from Brazil Amazon. PloS One, 2020; 15(5): 0232474.
MEDEIROS-FONSECA B, et al. Experimental models for studying HPV-positive and HPV-negative penile cancer: New tools for an old disease. Cancers, 2021; 13(3): 460.
Munn Z, et al. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and incidence data. Int J Evid Based Health. 2015; 13(3): 147–153.
OLESEN TB, et al. Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. The Lancet Oncology, 2019; 20(1): 145-158.
PORTAL DA UROLOGIA. 2022. In: Câncer de pênis. Disponível em: https ://portaldaurologia.org.br/publico/cancer-de-penis. Acessado em 23 de março de 2022.
SCHEINER M, et al. Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features. International Brazilian Journal of Urology, 2008; 34: 467-476.
SICHERO L, et al. Human papillomavirus, and genital disease in men: what we have learned from the HIM study. Acta Cytologica, 2019; 63(2): 109-117.
SILVA RJC, et al. HPV-related external genital lesions among men residing in Brazil. Brazilian Journal of Infectious Diseases, 2017; (21): 376-385.
SOARES A, et al. Penile cancer: a Brazilian consensus statement for low-and middle-income countries. Journal of Cancer Research and Clinical Oncology. 2020; 146: 3281-3296.
SOUSA ISDB, et al. Prevalence of human papillomavirus in penile malignant tumors: viral genotyping and clinical aspects. BMC Urology, 2015; 15(1): 1-6.
SUDENGA SL, et al. Country‐specific HPV‐related genital disease among men residing in Brazil, Mexico and The United States: the HIM study. International Journal of Cancer, 2017; 140(2): 337-345.
TERMINI L, et al. SOD2 immunoexpression predicts lymph node metastasis in penile cancer. BMC Clinical Pathology, 2015; 15(1): 1-8.
THOMAS A, et al. Penile cancer (Primer). Nature Reviews: Disease Primers, 2021; 7(1): 11.
VIEIRA CB, et al. A cohort study among 402 patients with penile cancer in Maranhão, Northeast Brazil with the highest worldwide incidence. BMC Research Notes, 2020; 13(1):1-3.
WENDLAND, EM et al. POP-Brazil Study Group. Prevalence of HPV infection among sexually active adolescents and young adults in Brazil: The POP-Brazil Study. Science Reports. 2020; 18;10(1): 4920.