Keywords
malaria
amazon
Antimalarial treatment
plasmodium spp
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Abstract
Objective: To explore and synthesize the available evidence on the use of Amazonian medicinal plants in the treatment of malaria, highlighting their mechanisms of action, challenges, and limitations. Literature Review: The review revealed that plants such as Cinchona spp., Artemisia annua, Carapa guianensis, Copaifera spp., and Quassia amara possess bioactive compounds that inhibit the replication of Plasmodium spp., modulate the host's immune response, and have antioxidant properties. The main challenges include parasite resistance to treatments, standardization of plant extract doses, and drug interactions. Integrating traditional knowledge with scientific research can lead to the development of new effective antimalarial treatments. Final Considerations: Amazonian medicinal plants demonstrate significant potential in the treatment of malaria; however, further studies are necessary to ensure the safety and efficacy of these treatments. Major limitations include parasite resistance to medications and the need for standardization of plant extracts. Additionally, logistical challenges in the collection and preservation of these plants must be addressed. Integrating traditional knowledge with scientific research could be key to developing new, effective antimalarial treatments.
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