Keywords
Delirium
Intensive Care Units
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Abstract
Objective: To analyze the effectiveness of using suvorexant in preventing delirium in critically ill patients. Methods: This is an integrative review carried out by searching for articles published in the last 10 years in the main electronic databases, PUBMED, SCIELO and Web of Science. Results: The search resulted in six studies that converged on the effectiveness of the use of suvorexant in preventing delirium in seriously ill patients. No adverse effects were found. A variation of 15 to 20 mg was observed in the administered dose of suvorexant for the prevention of delirium. The main risk factors for delirium related to patients in the Intensive Care Unit (ICU) were older age, higher frailty score, lower Body Mass Index, greater dementia, higher APACHE II score, increased use of ventilators and sleep disorders. An association was also found between the use of suvorexant and the use of mechanical ventilation, mortality, and co-administration of drugs, such as Trazodone. Final considerations: Suvorexant can be quite effective for the treatment of delirium in seriously ill patients, especially when considering the mild or absent adverse effects compared to those presented by antipsychotics widely used to control delirium.
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