Keywords
Subcutaneous infusion
Guides
Off-label use
Medication errors
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Abstract
Objective: To present the validation process of the medication guide for off-label subcutaneous use, regarding objectivity, content and language. Methods: Cross-sectional research developed in 2 stages: (1) construction of a virtual questionnaire with responses on a Likert scale and content validation by expert judges in two rounds; and (2) validation of the version approved in the first stage, by health professionals from a national reference institute in traumatology and orthopedics. For validation calculations, the Content Validation Index (CVI) and the percentage of agreement between participants were used. Results: The first version presented CVI = 0.91 and 80% agreement (n=10). For the 2nd round, version 2 presented obtained CVI = 0.97 and 90% agreement (n=10). Considered approved, this version 2 was then validated by the institute's health professionals (CVI = 0.98 and 90% agreement, n = 60). Conclusion: The guide was considered valid and legitimized by health professionals, enabling the acceptance and effective use of the SC route at the institute and promoting the safety of patients in orthopedic palliative care, through the standardization of good practices.
References
ALEXANDRE NM, COLUCI MZO. Validade de conteúdo nos processos de construção e adaptação de instrumentos de medidas. Ciência & Saúde Coletiva, 2011; 16: 3061-3068.
BRINGEL KKMC, et al. Construção e validação de um guia da rede SUS em um município da Baixada Maranhense. Research, Society and Development, 2022; 11(1): e43311125192.
CABAÑERO-MARTÍNEZ MJ, et al. Perceptions of health professionals on subcutaneous hydration in palliative care: A qualitative study. Palliative Medicine, 2016; 30(6): 549-557.
CABAÑERO-MARTÍNEZ MJ, et al. Availability and perceived usefulness of guidelines and protocols for subcutaneous hydration in palliative care settings. Journal of Clinical Nursing, 2019; 28(21-22): 4012-4020.
CACCIALANZA R, et al. Subcutaneous Infusion of Fluids for Hydration or Nutrition: A Review. JPEN. Journal of Parenteral and Enteral Nutrition, 2018; 42(2): 296-307.
CARVALHO DMDS. A Via subcutânea na gestão dos sintomas na pessoa em fim de vida: perspetivas dos profissionais de saúde. 2019.
CHAVES EF, et al. Off-label drug use in an adult intensive care unit of a Brazilian hospital. Brazilian Journal of Pharmaceutical Sciences, 2023; 58: e20238.
COELHO TA, et al. Hypodermoclysis as a Strategy for Patients With End-of-Life Cancer in Home Care Settings. The American Journal of Hospice & Palliative Care, 2020; 37(9): 675-682.
COLUCI MZO, et al. Construção de instrumentos de medida na área da saúde. Ciência & Saúde Coletiva, 2015; 20: 925-936.
CORREIA GB, BATISTA AM. Levantamento de informações para elaboração de guia de estabilidade de medicamentos injetáveis pós reconstituição e diluição em hospital materno-infantil. Infarma - Ciências Farmacêuticas, 2021; 33(1): 81-85.
DICKMAN A, et al. Identification of drug combinations administered by continuous subcutaneous infusion that require analysis for compatibility and stability. BMC Palliative Care, 2017; 16: 22.
DIONISI S, et al. Medication Errors in Intensive Care Units: An Umbrella Review of Control Measures. Healthcare (Basel, Switzerland), 2022; 10(7): 1221.
FORBAT L, et al. How and why are subcutaneous fluids administered in an advanced illness population: a systematic review. Journal of Clinical Nursing, 2017; 26(9-10): 1204-1216.
GOMES NS, et al. Nursing knowledge and practices regarding subcutaneous fluid administration. Revista Brasileira de Enfermagem, 2017; 70(5): 1096-1105.
GOMES NS, et al. Validação de instrumento para avaliação do conhecimento profissional acerca da hipodermóclise. Revista de Enfermagem e Atenção à Saúde, 2019; 8(1).
KOSZMA EIA, et al. Use of off-label medications in a neonatal intensive care unit. Revista Paulista de Pediatria, 2021; 39: e2020063.
LAHER AE, et al. Medication Errors at a Tertiary Hospital Intensive Care Unit. Cureus, 2021; 13(12): e20374.
MARÍN MZR, et al. Estrategias para la prevención de errores en la administración de medicamentos intravenosos. Investigación en Enfermería: Imagen y Desarrollo, 2021.
MOREIRA LP, et al. Use of off-label drugs and the prevalence of adverse reaction to drugs in the adult intensive care unit of a Brazilian public hospital. Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 2023; 14(1): 868.
NASCIMENTO IRC, et al. Validação de Protocolos de Avaliação Psicológica e Indicadores de Atendimento em Psico-Oncologia. Psicologia: Ciência e Profissão, 2021; 41: e225481.
NOVAES MRCG, et al. Guia de boas práticas em farmácia hospitalar e serviços de saúde. 2. ed. Barueri (SP): Manole, 2020; p. 1-405.
POLIT DF, BECK CT. Fundamentos de Pesquisa em Enfermagem - 7ed: Avaliação de Evidências para a Prática da Enfermagem. [s.l.] Artmed Editora, 2016.
PONTALTI G, et al. Via subcutânea: segunda opção em cuidados paliativos. Clinical and Biomedical Research, 2012; 32(2).
QUAGLIO RDC, et al. Medicamentos passíveis de infusão por hipodermóclise. Medicina (Ribeirão Preto), 2018; p. 55-68.
SANTOS GP, et al. Desenvolvimento de um guia de incompatibilidade em Y para medicamentos endovenosos em um Hospital Universitário de Sergipe. Research, Society and Development, 2023; 12(3): e26512340717.
SHOULDERS BR, et al. Characterization of Guideline Evidence for Off-label Medication Use in the Intensive Care Unit. The Annals of Pharmacotherapy, 2017; 51(7): 529-542.
SMITHBURGER PL, et al. A Multicenter Evaluation of Off-Label Medication Use and Associated Adverse Drug Reactions in Adult Medical Intensive Care Units. Critical Care Medicine, 2015; 43(8): 1612-1621.
VASCONCELLOS CF, MILÃO D. Hipodermóclise: alternativa para infusão de medicamentos em pacientes idosos e pacientes em cuidados paliativos. PAJAR - Pan-American Journal of Aging Research, 2019; 7(1): e32559.
VIDAL M, et al. A Prospective Study of Hypodermoclysis Performed by Caregivers in the Home Setting. Journal of Pain and Symptom Management, 2016; 52(4): 570-574.e9.
VIEIRA VC, et al. Prescription of off-label and unlicensed drugs for preterm infants in a neonatal intensive care unit. Revista Brasileira de Terapia Intensiva, 2021; 33(2).