Keywords
COVID-19
Immunosuppressants
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Abstract
Objective: to describe the effects of Covid-19 on kidney transplant (RTx) recipients. Methods: Descriptive, retrospective study carried out in a Hospital in Fortaleza, CE with RTx of both sexes, who developed Covid-19 in 2021. Data were collected: sociodemographic and clinical, underlying kidney disease; transplant date; type of donor; management of immunosuppression and Covid-19; serum creatinine (Cr) before and after Covid-19 and outcome. The analysis was carried out using the Jamovi program (v22.0). Results: In the sample of 73 patients, 50.7% were outpatients, 49.3% were hospitalized, 56.1% were men and 93.2% were deceased donors, with the most common symptoms being cough, fever and diarrhea. Older patients and those with longer Tx died more. Of the 25 patients with modified immunosuppression, 40% had a reduction in the antimetabolite and 28% its withdrawal, 12% a reduction in the antiproliferative, 12% an increase in corticosteroids and 8% a reduction in the calcineurin inhibitor. To manage Covid-19, corticosteroids, azithromycin and ivermectin were most used. After Covid-19, there was an increase in the mean Cr, with significance (p<0.05) for non-death and a decrease in the glomerular filtration rate with significance for death and non-death. A study showed a mortality rate of 28.8%. Conclusion: A better understanding of the procedures carried out was possible, generating updates to improve patient care.
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