Keywords
Focused ultrasound
Neuroinflammation
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To evaluate the impact of blood-brain barrier modulation by ultrasound focused on neuroinflammation, with a focus on the therapeutic implications for neurological and neurodegenerative diseases. Methods: Integrative review in PubMed Central (PMC). A total of 587 articles were initially selected. Based on strict inclusion and exclusion criteria, using only articles in English from 2020 to 2024, 17 articles were selected. Results: The use of focused ultrasound directly influences neuroinflammatory processes, by inducing the temporary opening of the blood-brain barrier, promoting the effect of increased penetration of immunological and pharmacological therapies, as well as the purifying process of proteins with cellular and neurogenic stimulation, also allowing cognitive improvement, without associated cell damage or death. Final considerations: Focused ultrasound is a promising and simple approach, allowing its use in neurodegenerative, neuroinflammatory, neuro-oncological processes and neuromotor disorders. However, further studies should be carried out in order to demonstrate the maximum therapeutic potential of this therapeutic category.
References
BATHINI e PRAVEEN, et al. Acute effects of focused ultrasound-induced blood-brain barrier opening on anti-pyroglu3 abeta antibody delivery and immune responses. Biomolecules, 2022; 12(7): 951.
CHANG WLK, et al. Rapid short‐pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain. Science Reports, 2023; 13: 6963.
CHAVES JCS, et al. Alzheimer's disease brain endothelial-like cells reveal differential drug transporter expression and modulation by potentially therapeutic focused ultrasound. Neurotherapeutics, 2024; 21(1): 299.
CHOI HJ, et al. The new insight into the inflammatory response following focused ultrasound-mediated blood–brain barrier disruption. Fluids and Barriers of the CNS, 2022; 19: 103.
DENG Z, et al. Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects. Journal of Oncology, 2019; 1: 2345203.
DUBEY S, et al. Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease. Proceedings of the National Academy of Sciences, 2020; 117(51): 32691–32700.
FISHER DG e PRICE RJ. Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System. Frontiers in Pharmacology, 2019; 10: 1348.
FISHMAN OS e FISCHELL JM. Focused ultrasound mediated opening of the blood-brain barrier for neurodegenerative diseases. Frontiers in Neurology, 2021; 12: 74904.
HAROON J, et al. Use of transcranial low-intensity focused ultrasound for targeted delivery of stem cell-derived exosomes to the brain. Scientific reports,2023; 13(1): 17707.
JEONG H, et al. A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease. Ultrasonography, 2021; 40(4): 512-519.
KONG C e CHANG WS. Preclinical Research on Ultrasound-Mediated Blood-Brain Barrier Opening for Neurological Disorders: A Review. Neurology International, 2023; 15(1): 285-300.
LAPIN NA, et al. Consistent opening of the blood brain barrier using focused ultrasound with constant intravenous infusion of microbubble agent. Scientific reports, 2020;10(1): 16546.
LEONOR K, et al. Transcranial short study of the focused clinical utrassound in the blood brain barrier. Nature in Neuroscience, 2020; 12(2): 250.
MCMAHON D, et al. Therapeutic Agent Delivery Across the Blood–Brain Barrier Using Focused Ultrasound. Annual Reviews, 2021; 23: 89-113.
PROFACI CP, et al. The blood–brain barrier in health and disease: Important unanswered questions. Journal of Experimental Medicine, 2020; 217: 20190062.
REZAI AR, et al. Focused ultrasound–mediated blood-brain barrier opening in Alzheimer’s disease: long-term safety, imaging, and cognitive outcomes. Journal of Neurosurgery, 2023; 139(11): 1-275–283.
RIGOLLET S, et al. FUS-mediated BBB opening leads to transient perfusion decrease and inflammation without acute or chronic brain lesion. Theranostics, 2024; 14(10): 4147-4160.
SCOTT K e KLAUS SP. Focused ultrasound therapy for Alzheimer’s disease: exploring the potential for targeted amyloid disaggregation. Frontiers in Neurology, 2024; 15(6).
SHEYBANI ND, et al. ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. Journal of controlled release: official journal of the Controlled Release Society, 2021; 331: 19-29.
SPIVAK NM, et al. Histological examination of focused ultrasound effects on human brain tissue. Brain Stimulation, 2021; 14: 1486-1488.
STEFANI A, et al. Neurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound? Frontiers in Neuroscience, 2022; 16: 846681.
THOMBRE R, et al. Towards standardization of the parameters for opening the blood–brain barrier with focused ultrasound to treat glioblastoma multiforme: A systematic review of the devices, animal models, and therapeutic compounds used in rodent tumor models. Frontiers in Oncology, 2023; 12: 1072780.
ZHAN W. Effects of focused-ultrasound-and-microbubble-induced blood-brain barrier disruption on drug transport under liposome-mediated delivery in brain tumour: A pilot numerical simulation study. Pharmaceutics 2020; 12(1): 69.