Keywords
Hypogammaglobulinemia
Thymoma
Myasthenia gravis
Neuroimmunology
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Abstract
Objective: To investigate a possible association between Myasthenia Gravis (MG) and Good's Syndrome (GS), since some patients can present them simultaneously and both are involved with the immune system. Bibliographic review: The selected articles highlight the central role of the thymus in both immune competence and control, suggesting that the connection between GS and MG is mainly related to thymic changes present in GS, which contribute to immunological dysregulation, leading to the production of antibodies anti-acetylcholine receptor (anti-AchR), characteristic of MG. These changes in the thymus are associated with an inadequate immune response, where T and B cells can interact anomalously, favoring autoimmunity. Furthermore, the presence of thymomas, frequently observed in patients with MG, highlights the importance of this organ in the genesis of the disease. Therefore, studies on the interaction between the immune system and the thymus offer new perspectives for understanding the association between GS and MG. Final considerations: The literature suggests an association between MG and GS. Therefore, GS should be considered in patients diagnosed with MG and vice versa.
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