Keywords
Intermittent infusion
Sepsis
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Abstract
Objective: To evaluate the efficacy of continuous and intermittent beta-lactam antibiotic infusion in the management of sepsis. Methods: This is an integrative review in which the main research focus was to find evidence on continuous and intermittent antibiotic infusion in sepsis management regarding mortality, recovery time, and prevention of bacterial resistance. The keywords used were “sepsis” OR “sepsis shock” AND “prolonged infusion” OR “intermittent infusion” OR “short-term”. The searches were conducted in the PubMed Central database, resulting in a total of 306 articles that were subjected to selection criteria. After applying these criteria, 20 articles were selected for this study. Results: Among the 20 articles analyzed, we found studies showing that prolonged infusion provided more benefits than intermittent infusion, studies that failed to show significant differences, studies that analyzed target doses of different antibiotics, and one study that assessed the effects of prolonged beta-lactam administration. Final considerations: It was found that the prolonged infusion of beta-lactam antibiotics shows benefits in patients with severe sepsis, such as reduced mortality and bacterial resistance, but there is still disagreement about its superiority, requiring further research to prove its effectiveness..
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