Keywords
Inflammatory bowel disease
Oral manifestations
Oral biofilm
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Abstract
Objective: To analyze the relationship between periodontal disease and inflammatory bowel disease (IBD). Bibliographic Review: Inflammatory bowel diseases (IBD) encompass several clinical conditions, in which the Chronic inflammation occurs in different parts of the digestive tract. Ulcerative colitis (UC) and Crohn's disease (CD) are the most typical forms of these conditions. Due to its connection with various manifestations that occur outside the digestive system, IBD can affect several organs and systems in the body, including the oral cavity. An association between periodontitis and intestinal inflammation has been confirmed, but whether IBD leads to periodontitis or whether periodontitis is a contributing factor to IBD remains controversial. Furthermore, identifying the predisposition profile can pave the way for the use of medications that reestablish the balance of the immune system, helping to control these conditions. Final considerations: It can be considered that periodontal pathogens and pro-inflammatory cytokines contributed to the exacerbation of the inflammatory process of chronic intestinal diseases. However, more randomized controlled clinical studies are needed to confirm this causal relationship.
References
ABROL N, et al. Doença inflamatória intestinal e periodontite: uma análise retrospectiva de prontuários. Clin. Exp. Dente. Res., 2020; 8: 1028–1034.
ATARASHI K, et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science, 2017; 358(6361), 359-365.
BERTL K, et al. Periodontitis prevalence in patients with ulcerative colitis and Crohn's disease - PPCC: A case–control study. Journal of Clinical Periodontology, 2022. 49(12), 1262–1274.
BRITO F, et al. Inter-relação entre a doença periodontal e a doença de Crohn. R. Ci. Méd. Biol., 2006; 5,3: 261-267.
CAMBUI YRS, NATALI MRM. Doenças inflamatórias intestinais: revisão narrativa da literatura. Revista da Faculdade de Ciências Médicas de Sorocaba, 2015; 17(3), 116-119.
CAMPOS HS. Papel do microbioma na resposta imune e na asma. Arq Asma Alerg Imunol., 2018; 2(2), 238-246.
CHAN SSM, et al. Carbohydrate Intake in the Etiology of Crohn’s Disease and Ulcerative Colitis. Inflamm Bowel Dis., 2014; 20(11): 13-21.
CHAPPLE ILC. Time to take periodontitis seriously. BMJ, 2014; 348: g2645.
COTRIM MA, et al. O papel da microbiota intestinal na patogênese das doenças inflamatórias intestinais. Brazilian Journal of Health Review, 2020; 3(3), 4558–4565.
FIGUEIREDO CM, et al. Activity of inflammatory bowel disease influences the expression of cytokines in gingival tissue. Cytokine, 2017; 95, 1-6.
FITZPATRICK SG e KATZ J. The association between periodontal disease and cancer: a review of the literature. J Dent 2010;38:83-95.
FLANAGAN D. Enterococcus faecalis and Dental Implants. J Oral Implantol, 2017; Feb;43(1):8-11.
GOLDINOVA A, et al. Oral health and United European Gastroenterol J. 2020; 8(9): 1067-1075.
GUARNER F. Papel de la flora intestinal en la salud y en la enfermedad. Nutrición Hospitalaria, Madrid, 2007; 22(2), 14-19.
HAJISHENGALLIS G. Periodontite: da subversão imunológica microbiana à inflamação sistêmica. Nat Rev Immunol., 2015; 15 (1):30–44.
HIENZ SA, et al. Mechanisms of bone resorption in periodontitis. Journal of Immunology Research, 2015.
IMAI J, et al. A potential pathogenic association between periodontal diasease and Crohn’s diasease. JCI Insight 6, 2021; e148543.
KAMINSKY LW, et al. IL-1β e a barreira de junção estreita epitelial intestinal. Frente. Imunol. 2021; 12.
KATZ J, et al. Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease. Oral Dis. 2003;9(1):34-40.
KIRSNER JB. Historical aspects of inflammatory bowel disease. J Clin Gastroenterol. 1988 Jun;10(3):286-97.
KÖNÖNEN E, GURSOY UK. Oral Prevotella species and their connection to events of clinical relevance in gastrointestinal and respiratory tracts. Front Microbiol., 2022; 12:798763.
LANKARANI KB, et al. Oral manifestation in inflammatory bowel disease: a review. World journal of Gastroenterology: WJG, 2013; 19.46.8571.
LARANJEIRA N, et al. Manifestações Orais da Colite Ulcerosa. Jornal of Dentistry. 2014; 1(8); 22–4.
LIU H, et al. Fusobacterium nucleatum exacerba a colite danificando as barreiras epiteliais e induzindo inflamação aberrant . J. Dig Dis., 2020; 21: 385–398.
MARTINS DC, et al. Microbiota intestinal e diabetes mellitus: associações intrínsecas. Rev Port Endocrinol Diabetes Metab., 2018; 13(2).
MENEGAT JSB, et al. Cytokine expression in gingival and intestinal tissues of patients with periodontitis and inflammatory bowel disease. Archives of Oral Biology, 2016; 66:141–146.
MERVIG G, et al. Molecular forms and fragments of salivary MMP-8 in relation to periodontitis.Journal of Clinical Periodontology, 2018; 45: 1421-1428.
MEYER MS, et al. A review of the relationship between tooth loss, periodontal disease and cancer. Cancer Causes Control 2008;19:895-907.
NEWMAN KL, KAMADA N. Associações patogênicas entre doenças bucais e gastrointestinais. Tendências Mol. Med., 2022; 28:1030–1039.
PAPAPANOU PN, et al. Periodontitis: Consensus Report of Workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Clinical Periodontology, 2018; 45:162-170.
SAID HS, et al. Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA research, 2014; 15-25.
SETE MRC, et al. Doença periodontal e lúpus eritematoso sistêmico. Rev. Bras. Reumatol, 2016; 56 (2): 165-170.
STEFFENS JP, MARCANTONIO RAC. Classificação das Doenças e Condições Periodontais e Peri-implantares 2018: Guia Prático e Pontos-Chave. Revista de odontologia da UNESP, Universidade Estadual Paulista (UNESP), 2018; 47. 189-197.
STUART CH, et al. Enterococcus faecalis: its role in root canal treatment failure and current concepts in retreatment. J Endod. 2006 Feb;32(2):93-8.
WADE WG. The oral microbiome in health and disease. Pharmacological Research, 2013; 69, 137–143.
WILKS S. Morbid appearances in the intestine of Miss Bankes. London Medical Gazette 1859; 2: 264.
WILKS S, MOXON W. Lectures on Pathological Anatomy. 2nd Ed. Philadelphia Lindsay and Blakiston 1875.
XUN Z, et al. Dysbiosis and Ecotypes of the Salivary Microbiome Associated With Inflammatory Bowel Diseases and the Assistance in Diagnosis of Diseases Using Oral Bacterial Profiles. Front Microbiol. 2018;9:1136.