Keywords
Sickle cell nephropathy
Angiopoietin-2
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Abstract
Objective: To demonstrate, through the existing scientific literature, the involvement of angiopoietin-2 in the development of sickle cell nephropathy. Literature review: Sickle cell anemia (SCA) is a hereditary hemoglobinopathy characterized by homozygosity of hemoglobin S (HbS) and is associated with vascular and inflammatory complications that can affect multiple organs, including the kidneys. The development of sickle cell nephropathy (SN) in patients with SCA is multifactorial, involving mechanisms such as intravascular hemolysis, vaso-occlusive events, ischemia-reperfusion injuries, endothelial dysfunction and pro-angiogenic state. Angiopoietin-2 (Ang-2) acts in angiogenesis and has been described as a biomarker of endothelial dysfunction and in the progression of nephropathy in different etiologies, being involved in the regulation of vascular permeability and in the activation of the inflammatory process. Final considerations: In the context of AF, hypoxia resulting from vaso-occlusion events and intravascular hemolysis induce the release of pro-angiogenic factors, such as Ang-2, aggravating renal injury through increased vascular permeability. In addition, several studies involving Ang-2 as a therapeutic target in diseases involving abnormal angiogenesis are under development, opening the way for a possible therapeutic management of complications caused by the pro-angiogenic state in patients with AF, including NF.
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