Keywords
Postpartum period
Central Nervous System
Nutritional deficiencies
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To investigate whether vitamin D deficiency may be associated with the development of postpartum depression, based on available scientific evidence. Methods: Integrative review, carried out in the PUBMED, BVS, SCIELO, MEDLINE and LILACS databases, with the Health Descriptors: “Postpartum Depression” AND “Vitamin D”. After a careful evaluation, 15 articles were selected from the total that comprise this study. Results: The authors address that vitamin D deficiency has a strong connection and is directly linked to postpartum depression, where after categorizing the studies, it was found that 86.6% (n = 13) obtained positive evidence on the subject, highlighting that vitamin D deficiency directly affects the mental health of pregnant and postpartum women. Thus, ensuring adequate levels of vitamin D during pregnancy can be an important preventive strategy, especially for women who are more vulnerable to depression. Final considerations: According to the data presented, it is observed that vitamin D deficiency is a significant risk factor for postpartum depression, but more concise studies are needed to emphasize this study.
References
ABEDI P, et al. The relationship between vitamin D and postpartum depression in reproductive-aged Iranian women. Journal of medicine and life, 2018; 11(4): 286.
ACCORTT EE, et al. Low prenatal vitamin D metabolite ratio and subsequent postpartum depression risk. Journal of Women's Health, 2021; 30(1): 113-120.
ACCORTT EE, et al. Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines. Archives of women's mental health, 2016; 19(2): 373-383.
ACCORTT EE, et al. Vitamin D deficiency and depressive symptoms in pregnancy are associated with adverse perinatal outcomes. Journal of Behavioral Medicine, 2018; 41(5): 680-689.
AGHAJAFARI F, et al. Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients, 2018; 10(4): 478.
AL-SABAH R, et al. Antenatal Depression and its Associated Factors: Findings from Kuwait Birth Cohort Study. Journal of epidemiology and global health, 2024; 14(3): 847-859.
BATEINEH S e ATOUM MF. Association between Vitamin D Levels During Pregnancy and Postpartum Depression: A Narrative Reviews. Iranian Journal of Nursing and Midwifery Research, 2024; 29(3): 290-296, 2024.
BRASIL. (FEBRASGO). Federação Brasileira das Associações de Ginecologia e Obstetrícia. Depressão Pós-parto. 2020. Disponível em: https ://www.febrasgo.org.br/media/k2/attachments/EdioZWebZAtualiz ada.pdf. Acessado em: 10 de fevereiro de 2025.
BRASIL. (FEBRASGO). Federação Brasileira das Associações de Ginecologia e Obstetrícia. Depressão Pós-parto. 2021. Disponível em: https ://sogirgs.org.br/area-do-associado/Depressao-Pos-parto-2021 .pdf. Acessado em: 10 de fevereiro de 2025.
BRASIL. MINISTÉRIO DA SAÚDE. Depressão pós-parto. 2022. Disponível em: https ://www.gov.br/s aude/pt-br/assuntos/saude-de-a-a-z/d/depressao-pos-parto. Acessado em: 10 de fevereiro de 2025.
CENTENO LO, et al. Is Serum Vitamin D Associated with Depression or Anxiety in Ante-and Postnatal Adult Women? A Systematic Review with Meta-Analysis. Nutrients, 2024; 16(21): 3648.
CIOBANU AM, et al. Severe vitamin D deficiency—a possible cause of resistance to treatment in psychiatric pathology. Medicina, 2023; 59(12): 2056.
CORSELLO A, et al. Vitamin D in pediatric age: Current evidence, recommendations, and misunderstandings. Frontiers in medicine, 2023; 10: 1107855.
DE SOUSA MN, et al. Trilhando o caminho do conhecimento: o método de revisão integrativa para análise e síntese da literatura científica. Observatorio de la economía latinoamericana, 2023; 21(10): 18448-18483.
DOMACASSÉ D, et al. Associations between Early-pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosomatic Medicine, 2024; 10: 1097.
EID A, et al. Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD). Metabolic Brain Disease, 2019; 34: 1781-1786.
EYLES DW. Vitamin D: Brain and behavior. Journal of Bone and Mineral Research Plus, 2021; 5(1): 10419.
FAZELIAN S, et al. Effect of vitamin D supplement on mood status and inflammation in vitamin D deficient type 2 diabetic women with anxiety: a randomized clinical trial. International journal of preventive medicine, 2019; 10(1): 17.
FERNANDES-MOLL M, et al. Ocurrencia y factores asociados con la depresión posparto en un área urbana de Brasil. Enfermería Global, 2023; 22(69): 134-166.
GHAEDRAHMATI M e ALIPOUR Z. The Association Between Post-Partum Depression and Nutrition and Dietary Patterns: Systematic Review. Iranian Journal of Nursing and Midwifery Research, 2024; 29(3): 280-289.
GOULD JF, et al. A systematic review of vitamin D during pregnancy and postnatally and symptoms of depression in the antenatal and postpartum period from randomized controlled trials and observational studies. Nutrients, 2022; 14(11): 2300.
HOLLINSHEAD VR, et al. Low Vitamin D Concentration Is Associated with Increased Depression Risk in Adults 20–44 Years Old, an NHANES 2007–2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status. Nutrients, 2024; 16(12): 1876, 2024.
LIN T, et al. Causal associations between vitamin D and postpartum depression: A bidirectional mendelian randomization study. Heliyon, 2024; 10(13).
MAEDA SS, et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Consenso, 2014; 412-414.
NOSHIRO K, et al. Association between Edinburgh postnatal depression scale and serum levels of ketone bodies and vitamin D, thyroid function, and iron metabolism. Nutrients, 2023; 15(3): 768.
RIBAMAR A, et al. Relação entre deficiência de vitamina D e depressão gestacional e pós parto. Nutrición Hospitalaria, 2020; 1238-1245.
RICHARD A, et al. Prevalence of vitamin D deficiency and its associations with skin color in pregnant women in the first trimester in a sample from Switzerland. Nutrients, 2017; 9(3): 260.
ROUHI M, et al. Vitamin D reduces postpartum depression and fatigue among Iranian women. British Journal of Midwifery, 2018; 26(12): 787-793.
SHUB A e MCCARTHY EA. Eficácia do programa de triagem e tratamento pré-natal para deficiência de vitamina D: um ensaio de campo randomizado estratificado. The Journal of Clinical Endocrinology & Metabolism, 2019; 104(2): 337-338.
SZPUNAR MJ. Association of antepartum vitamin D deficiency with postpartum depression: A clinical perspective. Public Health Nutrition, 2020; 7: 1173-1178.
TRUJILLO J, et al. A systematic review of the associations between maternal nutritional biomarkers and depression and/or anxiety during pregnancy and postpartum. Journal of affective disorders, 2018; 232: 185-203.
VAZIRI F, et al. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC pregnancy and childbirth, 2016; 16: 1-12.
WANG J, et al. Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies. Archives of gynecology and obstetrics, 2018; 298: 1045-1059.
YUAN Y, et al. The Association between Vitamin D Deficiency and Perinatal Depression: A Systematic Review and Meta-Analysis. Alpha Psychiatry, 2024; 6: 669.
ZEROFSKY MS, et al. Daily cholecalciferol supplementation during pregnancy alters markers of regulatory immunity, inflammation, and clinical outcomes in a randomized controlled trial. The Journal of Nutrition, 2016; 11: 2388-2397.