Abstract
Objective: To describe the clinical characteristics of patients who underwent gastroduodenopancreatectomy between 2022 and 2024 at a university hospital, as well as the histopathological findings of their surgical specimens. Methods: Biopsy request forms and histopathological reports were reviewed in the digital archives of the Pathology Unit of a university hospital. The information analyzed was: age, sex, frozen section biopsy, histopathological report, margin assessment, lymphatic, blood and neural vascular invasion and tumor size. Results: During this period, 37 gastroduodenopancreatectomy surgeries were performed in this hospital, with an average patient age of 58 years (SD=12.6), 27 (72.9%) of which were female and 10 (27.0%) were male. Thirty-two (86.4%) patients had malignant lesions, with the most prevalent histopathological diagnoses being pancreatic ductal adenocarcinoma (21.6%) followed by intestinal type adenocarcinoma (18.9%). Perineural invasion was found in 20 cases (54%) and blood vessel and/or lymphatic invasion in 13 (35%). Conclusion: The analysis of data relating to periampullary tumors and patients undergoing gastroduodenopancreatectomy surgery contributes to reinforcing epidemiological knowledge of these conditions, aiming at better patient care.
References
BOUVET M, et al. Factors influencing survival after resection for periampullary neoplasms. The American Journal of Surgery, 2000; 180(1): 13–17.
CHAVEZ JA, et al. Pancreatic frozen section guides operative management with few deferrals and errors. Archives of Pathology & Laboratory Medicine, 2022; 146(1): 84–91.
D´CRUZ JR, et al. Pancreatico duodenectomy (Whipple Procedure). Stat Pears Publishing, 2024.
DE OLIVEIRA ML, et al. Cholangiocarcinoma: Thirty-one-Year Experience With 564 Patients at a Single Institution. Annals of Surgery, 2007; 245(5): 755–762.
FERREIRA FERR, et al. Duodeno pancreatectomia: análise histopatológica de tumores periampulares. Revista de Medicina (São Paulo), 2020; 99(4): 366–373.
FISCHER HP e ZHOU H. Pathogenesis of carcinoma of the papilla of Vater. Journal of Hepato-Biliary-Pancreatic Surgery, 2004; 11(5): 301–309.
HATZARAS I, et al. Predictors of Survival in Periampullary Cancers Following Pancreatico duodenectomy. Annals of Surgical Oncology, 2010; 17(4): 991–997.
HE J, et al. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. Hepato-Pacreato-Billiari, 2014; 16(1): 83–90.
INCA. INSTITUTO NACIONAL DO CÂNCER. Estatísticas do Câncer. Mortalidade conforme a localização primária por tumor e sexo. Available: https ://www.gov.br/inca/pt-br/assuntos/cancer/n umeros. Acessed: May 3, 2025.
KAMARAJAH SK. Pancreatico duodenectomy for periampullary tumours: a review article based on Surveillance, End Results and Epidemiology (SEER) database. Clinical and Translational Oncology, 2018; 20(9): 1153–1160.
LIM JE, et al. Prognostic factors following curative resection for pancreatic adenocarcinoma. Annals of Surgery, 2003; 237(1): 74-85.
MURAKAMI Y, et al. Pancreatoduodenectomy for distal cholangiocarcinoma: prognostic impact of lymph node metastasis. World Journal of Surgery, 2007; 31(2): 337–342.
NAGTEGAAL ID, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology, 2020; 76(2): 182–188.
NELSON DW, et al. Examining the accuracy and clinical usefulness of intraoperative frozen section analysis in the management of pancreatic lesions. The American Journal of Surgery, 2013; 205(5): 613–617.
RADOJKOVIC M, et al. Histopathologic differentiation as a prognostic factor in patients with carcinoma of the hepatopancreatic ampulla of Vater. Journal of International Medical Research, 2018; 46(11): 4634–4639.
SANTOS JPLS. Adenocarcinoma da Ampola de Vater: perfil imunohistoquímico e fatores prognósticos. Dissertação de mestrado (Mestrado em Ciências Aplicadas à Cirurgia e à Oftamologia). Universidade Federal de Minas Gerais, 2016; 95.
TYSON GL e EL-SERAG HB. Risk factors for cholangiocarcinoma. Hepatology, 2011; 54(1): 173–184.
UIJTERWIJK BA, et al. Different periampullary types and subtypes leading to different perioperative outcomes of pancreatoduodenectomy: reality and not a myth; an international multicenter cohort study. Cancers, 2024; 16(5): 899-910.
WINTER JM, et al. 1423 Pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. Journal of Gastrointestinal Surgery, 2006; 10(9): 1199–1211.
ZHANG C, et al. Quality of life and gastrointestinal symptoms in long-term survivors of pancreatic cancer following pancreato duodenectomy. Annals of Surgery, 2023; 279: 842-849.
