Keywords
Yellow fever virus
Orthoflavivirus
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Abstract
Objective: Non-human primates (NHPs) present clinical manifestations similar to those observed in humans infected with the yellow fever virus (YFV), making them relevant models for research. This Integrative Literature Review (ILR) aimed to systematize existing knowledge on the use of NHPs in studies of the disease and to provide support for future research. Methods: Articles published between 2020 and 2024 and available in the Virtual Health Library (VHL) were analyzed. They were classified according to levels of evidence and evaluated using the IRAMuTeQ software (version 0.7 alpha 2), applying Descending Hierarchical Classification and Similarity Analysis. Results: Among the 89 studies identified, 11 met the inclusion criteria, all published in English across six countries. The similarity analysis highlighted the centrality of the terms “yellow fever virus” and “non-human primate,” evidencing their relevance to surveillance and monitoring. The grouping of “outbreak,” “Orthoflavivirus,” and “Brazil” indicated the country as an epicenter of research, favored by its high biodiversity and the contact between urban and wild environments. Low vaccination coverage emerges as a risk factor for new strains and the reemergence of the virus. Final considerations: NHPs are essential to understanding viral pathogenesis, strengthening epidemiological surveillance, and guiding strategies to control yellow fever.
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