Keywords
Angiotensin-converting enzyme
INDEL mutation
Meta-analysis
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Abstract
Objective: We conducted a systematic review and meta-analysis to evaluate the association between polymorphisms in the ACE and ACE2 genes and the development of diabetic neuropathy (DN). Methods: We searched six databases (NCBI/PubMed, MEDLINE, Cochrane Library, Virtual Health Library, Scielo, and Embase) as well as grey literature (Google Scholar and citations). Two independent reviewers selected the articles according to predefined inclusion and exclusion criteria. Results: The systematic literature search identified 114 records across the databases. At the end of the selection process, 5 studies were included in the qualitative analysis, and 4 studies were included in the quantitative analysis. All included studies were case-control studies conducted in Iraqi, Pakistani, and Turkish populations. Conclusion: According to the meta-analysis, the ID+DD genotypes of the ACE gene I/D polymorphism are associated with an increased risk of developing DN (OR = 1.43, CI = 1.01–2.03, p = 0.0464). Our analysis also suggests that the D allele is a risk marker for DN (OR = 1.42, CI = 1.19–1.68, p < 0.0001), with similar findings previously reported. Further observational studies in diverse populations are needed to confirm this association.
References
BAKA P, et al. Systemic inflammatory biomarkers in painful diabetic neuropathy. J Diabetes Complications, 2021; 35(10): 108017.
BELBASIS L e BELLOU V. Introduction to Epidemiological Studies. Methods Mol Biol, 2018; 1793.
COELHO DB, et al. Polymorphism of the angiotensin converting enzyme gene (ACE-I/D) differentiates the aerobic and speed performance of football players. J Sports Med Phys Fitness, 2022: 62(2).
COPPEY LJ, et al. ACE Inhibitor or Angiotensin II Receptor Antagonist Attenuates Diabetic Neuropathy in Streptozotocin-Induced Diabetic Rats. Diabetes, 2006; 55(2).
COSTA AM, et al. Efeitos do sistema renina-angiotensina-aldosterona e do polimorfismo I/D do gene da ECA no desempenho esportivo. Rev Bras Ciências do Esporte, 2009; 31(1).
DEGIRMENCI I, et al. Frequency of angiotensin-converting enzyme gene polymorphism in Turkish type 2 diabetic patients. Int J Clin Pract, 2005, 59(10).
DHUMAD MM, et al. Angiotensin-converting enzyme insertion/deletion (I/D) gene polymorphism in Iraqi type 2 diabetic patients: association with the risk of cardiac autonomic neuropathy. Egyptian J Med Hum Genet, 2020; 21(1).
DIAS RG, et al. Polimorfismos genéticos determinantes da performance física em atletas de elite. Rev Bras Medicina do Esporte, 2007; 13(3).
DONOGHUE M, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res, 2000; 87(5).
EGGER M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997; 315(7109).
EL ALAMI H,et al. Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis. Diabetes Metab Syndr, 2022; 16(1).
FELDMAN EL, et al. Diabetic neuropathy. Nat Rev Dis Primers, 2019; 5(1).
GAO Y, et al. Changes in nerve microcirculation following peripheral nerve compression. Neural Regen Res, 2013; 8(11).
GOREN T, et al. Investigation of Serum Angiotensin-Converting Enzyme (ACE) Concentration and ACE Gene Polymorphism in Patients With SARS-CoV-2 Pneumonia Admitted to the Emergency Department. Cureus, 2022; 14(11).
GUYTON AC, et al. Tratado de fisiologia médica. Rio de Janeiro: Grupo GEN, 2021; 14.
HARTL DL. Princípios de genética de população. FUNPEC, editor, 2008; 3.
INANIR A, et al. The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy. Gene, 2013; 530(2).
INSTITUTE TJB. JBI Reviewer’s Manual. Joanna Briggs Institute, 2022.
ITO H, et al. Angiotensin-converting Enzyme Insertion/Deletion Polymorphism and Polyneuropathy in Type 2 Diabetes without Macroalbuminuria. J Int Med Res, 2002; (30).
KAKU M, et al. Pathways in the Diagnosis and Management of Diabetic Polyneuropathy. Curr Diab Rep, 2015; 15(6).
KHALAF KM, et al. Vitamin B12 status and peripheral neuropathy in patients with type 2 diabetes mellitus. J Pak Med Assoc, 2019; 69(3).
KHAN A, et al. Association of ACE Gene Insertion/Deletion Polymorphism with Diabetic Peripheral Neuropathy in Population of Khyber Pakhtunkhwa Pakistan. Fresenius Environmental Bulletin, 2021; 30(4).
KOBAYASHI M e ZOCHODNE DW. Diabetic neuropathy and the sensory neuron: New aspects of pathogenesis and their treatment implications. J Diabetes Investig, 2018; 9(6).
KRAMES ES. The Role of the Dorsal Root Ganglion in the Development of Neuropathic Pain. Pain Medicine, 2014; 15(10).
LI Y e TONG N. Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis. J Renin Angiotensin Aldosterone Syst, 2015; 16(4).
LUO R, et al. The Influence of Angiotensin Converting Enzyme and Angiotensinogen Gene Polymorphisms on Hypertrophic Cardiomyopathy. PLoS One, 2013; 8(10).
MAIRGHANI M, et al. The prevalence and incidence of diabetic foot ulcers among five countries in the Arab world: a systematic review. J Wound Care, 2017; 26(9).
MANSOOR Q, et al. Angiotensin-converting enzyme (ACE) gene II genotype protects against the development of diabetic peripheral neuropathy in type 2 Diabetes Mellitus. J Diabetes, 2012; 4(3).
MARRE M, et al. Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications. Diabetes, 1994; 43(3).
MOHAMMEDI K, et al. Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients with Long-Standing Type 1 Diabetes. Diabetes Care, 2022; 45(2).
MONTGOMERY HE, et al. Association of Angiotensin-Converting Enzyme Gene I/D Polymorphism with Change in Left Ventricular Mass in Response to Physical Training. Circulation, 1997; 96(3).
MUSAMBIL M e SIDDIQUI K. Genetics and genomics studies in type 2 diabetes: A brief review of the current scenario in the Arab region. Diabetes Metab Syndr, 2019; 13(2).
OLIVARES-REYES JA, et al.. Angiotensin II and the development of insulin resistance: Implications for diabetes. Mol Cell Endocrinol, 2009; 302(2).
OUZZANI M, et al. Rayyan - a web and mobile app for systematic reviews. Syst. Rev, 2016; 5(210).
PAGE MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021; 372(71).
PAPANAS N e ZIEGLER D. Polyneuropathy in Impaired Glucose Tolerance: Is Postprandial Hyperglycemia the Main Culprit? A Mini-Review. Gerontology, 2013; 59(3).
PARK S, et al. Recent advances in the pathogenesis of microvascular complications in diabetes. Arch Pharm Res, 2019; 42(3).
RIGAT B, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clinic Invest, 1990; 86(4).
SETTIN A, et al. Association of ACE and MTHFR genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications. J Renin Angiotensin Aldosterone Syst, 2015; 16(4).
SEYEDIZADEH SH, et al. The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials). J Diabetes Res, 2020.
SPALLONE V e GRECO C. Painful and Painless Diabetic Neuropathy: One Disease or Two? Curr Diab Rep, 2013; 13(4).
STEPHENS JW, et al. The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects. Mol Genet Metab, 2005; 84(1).
TIKHOMIROVA VE, et al. ACE phenotyping in human heart. PLoS One, 2017; 12(8).
WU S, et al. Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis. Mol Neurobiol, 2017; 54(4).
YOREK MA. Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy. Rev Diabet Stud, 2015; 12(1–2).
YU ZY, et al. Meta-analysis of the relationship between ACE I/D gene polymorphism and end-stage renal disease in patients with diabetic nephropathy. Nephrology, 2012; 17(5).
ZHONG W, et al. Improved neural microcirculation and regeneration after peripheral nerve decompression in DPN rats. Neurol Res, 2017; 39(4).