Keywords
Oral Mucositis
Photobiomodulation
, Antineoplastic Therapies
Quality of Life
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Abstract
Objective: To evaluate the level of knowledge of cancer patients regarding low-level laser therapy in the treatment of oral mucositis, as well as dental care in the hospital setting. Methods: A cross-sectional, quantitative study was conducted in a private hospital in the city of Maceió, with 21 patients undergoing antineoplastic therapies. Data collection was carried out using structured questionnaires administered in person. As a complementary instrument, a literature review was conducted for theoretical support. The data obtained were statistically analyzed using the chi-square test. Results: A significant improvement in quality of life and pain relief was observed after the use of photobiomodulation as adjuvant therapy. However, patients showed a lack of knowledge regarding the role of hospital dentistry and the existence of laser therapy in the prevention and treatment of mucositis. Conclusion: Laser therapy proved to be effective, safe, and with the potential to promote better clinical outcomes in cancer patients, reinforcing the need for integrated dental care within multidisciplinary teams.
References
AGBELE AT, HEJAZI SM, DEHPOUR AR, et al. Treatment parameters of photobiomodulation in the prevention of non surgical cancer treatment induced oral mucositis: a review of preclinical studies. J Lasers Med Sci, 2021; 12: e54.
ANTUNES HS, SILVA MA, QUEIROZ CC, et al. Photobiomodulation for the prevention of oral side effects secondary to head and neck cancer therapy: results of a randomised, single blind clinical trial. Supportive Care in Cancer, 2023;31(6):287–296.
BOURBONNE V, MARIE A, DELAQUETTE C, et al. Low-level laser therapy in the treatment of oral mucositis in head and neck cancer patients: a randomized controlled trial. Lasers in Medical Science, 2019;34(2):329–337.
BUGLIONE M, et al. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: literature review and consensus recommendations. Supportive Care in Cancer, 2016;24(5):2417–2431.
CAVALCANTI ET, SILVA JF, SOUSA J, et al. Complicaçõesoraisempacientessubmetidos à quimioterapia e radioterapia: revisãointegrativa. Revista Brasileira de Odontologia, 2018;75(2):129–135.
CRONSHAW M, PARKER S, ANAGNOSTAKI E, MYLONA V, LYNCH E, GROOTVELD M. Photobiomodulation and oral mucositis: a systematic review. Dentistry Journal, 2020;8(3):87.
ELAD S, YAROM N, HOVAN A, et al. Effect of low-level laser therapy in treatment of chemotherapy-induced oral mucositis. Journal of Clinical and Experimental Dentistry, 2019;11(4):e389–e395.
FIGUEIREDO LC, LIMA MO, OLIVEIRA DA, et al. Fatoresassociados à gravidade da mucosite oral empacientessubmetidos à radioterapia. Journal of Oral Pathology & Medicine, 2013;42(5):371–377.
KLASTERSKY J, DE NAUROIS J, ROLSTON K, RAPOPORT B, MASCHMEYER G, AAPRO M, HERRSTEDT J. Management of febrile neutropaenia: ESMO Clinical Practice Guidelines. Annals of Oncology, 2016; 27(suppl.5): v111–v118.
KUSIAK A, JERECZEK-FOSSA BA, CICHOŃSKA D, ALTERIO D. Oncological therapy related oral mucositis as an interdisciplinary problem — literature review. International Journal of Environmental Research and Public Health, 2020;17(7):2464.
LALLA RV, BOWEN J, BARASCH A, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 2014;120(10):1453–1461. PMID: 24782001.
LICA RA, MOREIRA MS, PEREIRA LR, et al. Impacto das lesõesmucosas no prognóstico do câncer: umarevisão. Revista Brasileira de Cancerologia, 2015;61(3):201–208.
LIMA VHS de, OLIVEIRA NETO OB, DA HORA SALES PH, DA SILVA TORRES T, CAMELLO DE LIMA FJ. Effectiveness of low level laser therapy for oral mucositis prevention in patients undergoing chemoradiotherapy for the treatment of head and neck cancer: a systematic review and meta-analysis. Lasers in Medical Science, 2019;34(2):329–337.
LOPES JC, SANTOS CP, OLIVEIRA RM, et al. Prevalência e características da mucosite oral empacientes com câncer de cabeça e pescoço. Revista Odontológica do Brasil Central, 2016;25(72):181–187.
MELO LC, BARBOSA FR, GOMES LS, et al. Complicaçõesorais e nutriçãoempacientesoncológicos: umaabordagemintegrada. Journal of Nutrition and Oncology, 2022;8(1):12–20.
MINAYO MCS. O desafio do conhecimento: pesquisaqualitativaemsaúde. 14. ed. São Paulo: Hucitec, 2014; 382 p.
MOBADDER M, NAZZAL A, KARA R. Photobiomodulation for prevention and treatment of oral mucositis: clinical guidelines and mechanisms. Oral Oncology, 2018; 78: 118–126.
OBEROI S, ZAMPERLINI-NETTO G, BEYENE J, TREISTER N, SUNG L. Effect of photobiomodulation therapy on oral mucositis: a systematic review and meta-analysis. Journal of the National Cancer Institute (JNCI), 2022;114(5):628–636. PMID: 35138335.
PETERSON DE, et al. Chemotherapy or radiation-induced oral mucositis. Supportive Care in Cancer, 2014;22(4):895–901. PMID: 24655526.
RUPPEL M, MORAES MM, SANTOS SM, et al. Cuidadosodontológicos no pacienteoncológico: importância e abordagemmultidisciplinar. Journal of Health Sciences, 2022;24(1):45–52.
SAMPAIO RF, MANCINI MC. Estudos de caso e suasaplicaçõesnapesquisaemreabilitação. Revista Brasileira de Fisioterapia, 2007;11(3):207–211.
SHEN B, ZHOU Y, WU D, LIU J. Efficacy of photobiomodulation therapy in the management of oral mucositis in patients with head and neck cancer: a systematic review and meta analysis of randomized controlled trials. Head & Neck, 2024;46(4):–.
SILVA GB, ANTUNES HS, ARAÚJO CTF, et al. Photobiomodulation therapy prevents dysgeusia chemotherapy induced in breast cancer women treated with doxorubicin plus cyclophosphamide: a triple-blinded, randomized, placebo-controlled clinical trial. Supportive Care in Cancer, 2021;29(12):7265–7273.
SILVA RL, SOUZA MM, ALMEIDA MT, et al. Efeitos da laserterapiaemprotocolos de mucosite oral: umarevisãosistemática. Brazilian Journal of Oncology, 2019;15(4):229–236.
SONIS ST. The pathobiology of mucositis. Nature Reviews Cancer, 2004; 4: 277–284. PMID: 15057285.
WEN S, et al. Update on the treatment of chemotherapy and radiotherapy induced buccal mucositis: a systematic review. Acta Odontológica Latinoamericana, 2023;36(1):3–14. PMID: 37314054.
ZADIK Y, ELAD S, YAROM N, et al. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients. Supportive Care in Cancer, 2019;27(11):3969–3983. PMID: 30758514.
ZECHA JA, RODOLOFO M, DELLA GRECA T, et al. Laser therapy in the management of oral mucositis: a systematic review. Supportive Care in Cancer, 2016;24(5):2193–2206.