Keywords
Prostate cancer
Annonaceae
Cytotoxic activity
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Abstract
Objective: To demonstrate the use of soursop (Annona muricata) as an agent against prostate cancer through scientific data. Methods: This is an integrative review with searches in three databases (Scielo, Pubmed and Periódicos CAPES), using pre-defined keywords and having been published between 2020 and 2025. Results: Ten studies as the final sample, all of which demonstrated the pharmacological effects of Annona muricata on cancer cells were selected. The studies also demonstrated the presence of several bioactive compounds in A. muricata, characterizing it as a cytotoxic and anticancer agent against prostate cancer. Conclusion: This integrative review showed that soursop is a plant with excellent anticancer potential and performance to be used as an alternative or complementary therapy in prostate cancer, considering that its bioactive compounds can increase the intracellular concentration of chemotherapeutic agents, in addition to acting on cell death, either through apoptosis or activating another alternative pathway to eliminate cytotoxic cells.
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