Keywords
Cannabidiol
Kidney
Liver
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Abstract
Objective: To evaluate the effects of cannabidiol (CBD) nanoemulsion in rats subjected to gestational protein malnutrition on the reversal of hepatic and renal alterations in the offspring. Literature review: Scientific evidence indicates that maternal protein deficiency is associated with increased oxidative stress, inflammation, and cellular dysfunctions, which may result in irreversible morphofunctional impairments depending on the gestational period during which nutritional restriction occurs. In this context, cannabidiol (CBD) nanoemulsion emerges as a promising therapeutic strategy due to its antioxidant, anti-inflammatory, and endocannabinoid system–modulating properties. Final considerations: The findings demonstrate that CBD nanoemulsion enhances compound bioavailability, reduces reactive oxygen species, and attenuates inflammatory responses, contributing to the structural and functional preservation of hepatic and renal tissues. Despite the promising results, further studies are required to standardize dosing and to assess maternal–fetal safety.
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