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Infraclavicular block with bupivacaine alone compared with bupivacaine combined with lidocaine in the surgical treatment of upper limb fractures
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Keywords

Brachial plexus block
Bupivacaine
Lidocaine
Radius fractures

How to Cite

Infraclavicular block with bupivacaine alone compared with bupivacaine combined with lidocaine in the surgical treatment of upper limb fractures. (2026). Electronic Journal Collection Health, 26(2), e22955. https://doi.org/10.25248/reas.e22955.2026

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Abstract

Objective: To compare the latency of infraclavicular block between the use of bupivacaine alone and bupivacaine combined with lidocaine in forearm fracture surgeries. Methods: A randomized clinical study conducted at Hospital Maradei (Belém, PA, Brazil) including 42 patients. Epidemiological profile, pain intensity (VAS), and muscle strength (BMRC) were assessed at 5 and 10 minutes post-block in the control group (0.5% bupivacaine) and the intervention group (0.25% bupivacaine plus 1% lidocaine). Results: The groups were comparable regarding sex and BMI; however, the intervention group showed a higher proportion of ASA I patients (76.2%; p=0.0443) and individuals with diabetes mellitus. A statistically significant reduction in pain was observed in the intervention group at 5 minutes (p=0.0028) and 10 minutes (p=0.0038). No significant differences in muscle strength were found between groups (p>0.05). Conclusion: The anesthetic combination accelerated sensory latency without anticipating immediate motor block. The study highlights the safety of the technique and underscores the need for further research on the total duration of analgesia in this population.

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References

AGUILERA G, et al. 0.25% bupivacaine–1% lidocaine vs 0.5% bupivacaine for ultrasound-guided infraclavicular brachial plexus block: a randomized controlled trial. Regional Anesthesia and Pain Medicine, 2025; 50(8): 627–634.

ALMASI R, et al. Onset times and duration of analgesic effect of various concentrations of local anesthetic solutions in standardized volume used for brachial plexus blocks. Heliyon, 2020; 6(9): e04718.

ARP AS, et al. The anesthetic effects of lidocaine with epinephrine in digital nerve blocks: a systematic review. Journal of the American Podiatric Medical Association, 2023; 113(4): 21–066.

BAŞKAN S et al. Determinação do volume mínimo efetivo de bupivacaína para bloqueio do plexo braquial infraclavicular guiado por ultrassom: estudo prospectivo, observador-cego e controlado. Brazilian Journal of Anesthesiology, 2022; 72(2):280-285.

CAMPAGNE D. Fraturas da diáfise da ulna e do rádio. Manual MSD – versão para profissionais de saúde. 2022. Disponível em: https://www.msdmanuals.com/. Acesso em: 16 abr. 2025.

CANSIAN JM, et al. Comparative effectiveness of bupivacaine and lidocaine-bupivacaine mixtures in brachial plexus block: a systematic review and meta-analysis. Anesthesia and Pain Medicine, 2025; 20(3):252-265.

CESUR S, et al. A randomized comparison between ultrasound-guided costoclavicular and infraclavicular block for upper extremity surgery. Turkish Journal of Medical Sciences, 2021; 51(4):1883-1888.

COTTER JT, et al. Increased body mass index and ASA physical status IV are risk factors for block failure in ambulatory surgery: an analysis of 9,342 blocks. Canadian Journal of Anesthesia, 2004; 51(8):810-816.

DE CASSAI A, et al. Regional anesthesia in obese patients: challenges, considerations, and solutions. Saudi Journal of Anaesthesia, 2025; 19(2):221-226.

GABRIEL RA, et al. The association of body mass index with same-day hospital admission, postoperative complications, and 30-day readmission following day-case eligible joint arthroscopy: a national registry analysis. Journal of Clinical Anesthesia, 2020; 59:26-31.

GEBHARD RE, et al. Diabetes mellitus, independent of body mass index, is associated with a higher success rate for supraclavicular brachial plexus blocks. Regional Anesthesia and Pain Medicine, 2009; 34(5):404-407.

MAGA JM, et al. Outpatient regional anesthesia for upper extremity surgery update (2005 to present) distal to shoulder. International Anesthesiology Clinics, 2012; 50(1):47-55.

MUIR D, et al. Supraclavicular versus infraclavicular brachial plexus block in upper limb orthopaedic surgery: a systematic review and meta-analysis of randomised controlled trials. European Journal of Orthopaedic Surgery & Traumatology, 2024; 34(8): 4123–4131.

PATEL DS et al. Common fractures of the radius and ulna. American Family Physician, 2021; 103(6):345-354.

PICARD L, et al. Impact of regional block failure in ambulatory hand surgery on patient management: a cohort study. Journal of Clinical Medicine, 2020; 9(8):2453.

RAFI BM, TIWARI V. Forearm fractures. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK574580/. Acesso em: 20 abr. 2025.

RUBENSTEIN WJ et al. The impact of body mass index on complications after shoulder arthroscopy: should surgery eligibility be determined by body mass index cutoffs? Arthroscopy, 2019; 35(3):741-746.

SILVA NETO OB, et al. Efeitos do uso de vasoconstritores no bloqueio de nervos digitais: revisão sistemática com metanálise. Revista do Colégio Brasileiro de Cirurgiões, 2019; 46(6):e20192269.

SRIPRIYA R, et al. Equal mixture of 2% lidocaine with adrenaline and 0.5% bupivacaine provided faster onset of complete conduction blockade during ultrasound-guided supraclavicular brachial plexus block: a randomized double-blinded clinical trial. Regional Anesthesia and Pain Medicine, 2024; 49(2): 104–109.

STEENSBÆK MT, et al. Effectiveness of combining lidocaine and ropivacaine on the duration of analgesia and anesthesia of an infraclavicular brachial plexus block. Local and Regional Anesthesia, 2025; 18: 17–25.

WAHEED Z, et al. General anesthetic care of obese patients undergoing surgery: a review of current anesthetic considerations and recent advances. Cureus, 2023; 15(7):e41565.