Abstract
Objective: To analyze the occurrence of Lymphoid Leukemias in children aged 0 to 19 years in the Northern region of Brazil, from 2015 to 2024. Methods: A quantitative, descriptive epidemiological study using data from DATASUS. Parameters included age group, sex, federative unit, and a comparison between Lymphoid Leukemia and Myeloid Leukemia. Results: Lymphoid leukemias are classified as acute lymphoid leukemia (ALL) and chronic lymphoid leukemia (CLL). An analysis between 2015 and 2024 showed that acute lymphoid leukemia had a higher incidence in children aged 2 to 5 years, with 788 cases registered, out of a total of 2,346 cases. It was found that there were more cases in males (1,368 cases) than in females (978 cases). Pará had the highest number of cases, with 1,439 cases. It was found that Lymphoid Leukemias are more frequent than Myeloid Leukemias, with 2,346 cases of Lymphoid Leukemia and 345 cases of Myeloid Leukemia recorded. Conclusion: It is concluded that the identification of genetic and socioeconomic factors is of great importance for diagnosis in the Northern region, as well as for supporting public policies, prevention strategies, early diagnosis, and improved access to pediatric health services, especially in regions with significant inequalities.
References
ALMAIMAN A, et al. Perfil proteômico da leucemia linfoide. Revista do Colégio de Médicos e Cirurgiões – Paquistão: JCPSP, 2018; 28(2): 133-145.
CARDIS E, et al. Radiation dose and cancer risk: assessment of studies of nuclear workers. Radiation Research, 2007; 167(4): 396–416.
CARVALHO R, et al. Incidência de linfomas e leucemias na Região Norte (2013–2023). J. Health Biol. Sci., 2025; 13(1): e5798.
CLARKE A, et al. X chromosome gene activation in female immune cells. PMC, 2016. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833277/. Acessado em: 9 de novembro de 2025.
DE SOUZA HDSC, et al. Panorama epidemiológico das internações por leucemia em crianças até 9 anos no Brasil (2019–2023). Brazilian Journal of Implantology and Health Sciences, 2024; 6(8): 5173–5187.
FERREIRA JM. Incidência, mortalidade e sobrevida de leucemia e linfoma no município de Fortaleza, Ceará. Dissertação — Fiocruz, 2010.
HARRISON CJ. Preventing childhood leukaemia through lifestyle changes. Leukemia, 2021; 35(5): 1265–1266.
IBGE. Pará – Cidades e Estados. Disponível em: https://www.ibge.gov.br/cidades-e-estados/pa.html. Acessado em: 1 out. 2025.
INCA. Leucemia. Rio de Janeiro: INCA, 2024. Disponível em: https://www.gov.br/inca. Acessado em: 31 out. 2025.
INCA. Estimativa 2023: Incidência de câncer no Brasil. Rio de Janeiro: INCA, 2023. Disponível em: https://www.inca.gov.br/estimativa. Acessado em: 31 out. 2025.
LU X, et al. X chromosome-linked tumor suppressor genes and leukemia susceptibility in males. PMC, 2017.
MALARD F, et al. Acute lymphoblastic leukaemia. The Lancet, 2020; 395: 1146–1162.
RESENDE DPM, et al. Perfil epidemiológico da leucemia linfoide em Minas Gerais (2017–2024). Hematology, Transfusion and Cell Therapy, 2024; 46(S4): S1046.
RIES L. SEER Cancer Statistics Review, 1975–2002. Disponível em: https://seer.cancer.gov/archive/csr/1975_2002/. Acessado em: 23 jun. 2025.
SCHRÄDER JR, et al. Uma análise da LLA em crianças com síndrome de Down. Revista Caderno Pedagógico, 2024; 21(8): 1–14.
SIEGEL RL, et al. Cancer statistics 2024. CA Cancer J Clin, 2024; 74(1): 12–49.
SILVA FF, LATORRE MRDO. Sobrevida das LLA em crianças de SP. Cadernos de Saúde Pública, 2020; 36(3): e00008019.
SILVA GCP, et al. Exposição parental a pesticidas e risco de leucemia infantil. Hematology, Transfusion and Cell Therapy, 2024; 46(S4): S1-S1267.
SMITH J, et al. Estrogen-mediated immune protection and apoptosis in hematopoietic cells. PMC, 2020.
VAN MAELE-FABRY G, et al. Exposure to pesticides and childhood leukemia risk. Environmental Pollution, 2021; 285: 117376.
