Keywords
Renal Replacement Therapy
Sepsis
Intensive Care Units
Critical Care Outcomes
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Abstract
Objective: To identify the factors influencing the clinical outcomes of adult patients admitted to the Intensive Care Unit with sepsis-associated acute kidney injury (SA-AKI). Methods: Scoping review. The search was conducted in the LILACS, PubMed/MEDLINE, Scopus, and Web of Science databases. The sample contains 19 articles published between 2020 and 2024. Authors, year, country, methodological design, and results were extracted. Subsequently, they were selected by reading the title and abstract and, later, by full reading, with categorization by clinical outcomes. The synthesis of the results was descriptive. Results: The studies demonstrated that early onset of SA-AKI, persistent renal dysfunction, and greater clinical severity are associated with worse clinical outcomes. Factors such as hemodynamic disturbances, positive fluid balance, emerging biomarkers, chronic kidney disease, obesity, and metabolic differences significantly influenced these outcomes. A concentration of Asian studies and an absence of Brazilian studies were observed. Final considerations: The findings reinforce the relevance of early recognition of SA-AKI and continuous renal risk stratification. The scarcity of national studies and methodological heterogeneity constitute important limitations.
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