Keywords
Clinical outcomes
Prognosis
Complications
Hospital mortality
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To identify in the literature the clinical outcomes in patients diagnosed with Takotsubo Syndrome. Methods: This is an integrative literature review, where the selection of publications was carried out using the Virtual Health Library (VHL) and PubMed databases. The search terms used in PubMed were: PubMed: "Takotsubo Cardiomyopathy", "Prognosis" using the Boolean operator AND, and in the Virtual Health Library (VHL): "Takotsubo Cardiomyopathy", "Prognosis", linked by the Boolean operator AND. Results: 322 articles indexed in the Virtual Health Library (VHL) and 712 in PubMed were found. 16 articles were selected for the final sample. Final considerations: Takotsubo cardiomyopathy, although generally reversible, can be associated with relevant clinical outcomes, especially during the acute phase and in long-term follow-up. Among the main complications observed are cardiogenic shock, heart failure, atrial fibrillation, ventricular arrhythmias, thromboembolic events, and hospital mortality. Factors such as reduced ejection fraction, need for catecholamine support, and presence of atrial fibrillation were associated with a worse prognosis. Therefore, early recognition of the condition is crucial. It is fundamental for optimizing therapeutic management, reducing complications, and improving clinical outcomes.
References
ABANADOR-KAMPER N, et al. Evaluation of therapy management and outcome in Takotsubo syndrome. BMC Cardiovasc Disord, 2017; 17(1): 176–188.
ABANADOR-KAMPER N, et al. Temporarily increased stroke rate after Takotsubo syndrome: need for an anticoagulation? BMC Cardiovasc Disord, 2018; 18(1): 1–5.
ALMENDRO-DELIA M, et al. Recovery of left ventricular function and long-term outcomes in patients with Takotsubo syndrome. J Am Coll Cardiol, 2024; 84(13): 1163–1174.
ANSARI U, et al. Clinical outcomes associated with catecholamine use in patients diagnosed with Takotsubo cardiomyopathy. BMC Cardiovasc Disord, 2018; 18(1): 1–8.
BENTO D, et al. Short- and medium-term prognosis of Takotsubo syndrome in a Portuguese population. Rev Port Cardiol, 2019; 38(5): 349–357.
BÖHM M, et al. Interaction of systolic blood pressure and resting heart rate with clinical outcomes in Takotsubo syndrome: insights from the international Takotsubo registry. Eur J Heart Fail, 2018; 20(6): 1021–1030.
CHAZAL HM, et al. Stress cardiomyopathy diagnosis and treatment. J Am Coll Cardiol, 2018; 72(16): 1955–1971.
CITRO R, et al. Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction. Eur J Heart Fail, 2019; 21(6): 781–789.
DOYEN D, et al. Incidence, clinical features and outcome of Takotsubo syndrome in the intensive care unit. Arch Cardiovasc Dis, 2020; 113(3): 176–188.
EKENBÄCK C, et al. Coronary microvascular dysfunction in Takotsubo syndrome and associations with left ventricular function. ESC Heart Fail, 2023; 10(4): 2395–2405.
EL-BATTRAWY I, et al. Impact of atrial fibrillation on outcome in Takotsubo syndrome: data from the international Takotsubo registry. J Am Heart Assoc, 2021; 10(15): 14059.
EL-BATTRAWY I, et al. Impact of concomitant atrial fibrillation on the prognosis of Takotsubo cardiomyopathy. Europace, 2016; 19(8): 1288–1292.
GHADRI JR, et al. International expert consensus document on Takotsubo syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J, 2018; 39(22): 2032–2046.
GLAVECKAITĖ S, et al. Clinical features and three-year outcomes of Takotsubo (stress) cardiomyopathy. Hellenic J Cardiol, 2016; 57(6): 428–434.
GUPTA S, et al. Takotsubo syndrome. Indian Heart J, 2018; 70(1): 165–174.
HSU JT, et al. Critical convex-type ST elevation correlates with ventricular tachyarrhythmia in Takotsubo cardiomyopathy. Clin Cardiol, 2024; 47(12): 1–9.
JESEL L, et al. Atrial arrhythmias in Takotsubo cardiomyopathy: incidence, predictive factors, and prognosis. Europace, 2019; 21(2): 298–305.
MATSUSHITA K, et al. Incomplete recovery from Takotsubo syndrome is a major determinant of cardiovascular mortality. Circ J, 2021; 85(10): 1823–1831.
MENDES KDS, et al. Integrative literature review: a research method to incorporate evidence in health and nursing. Texto Contexto Enferm, 2008; 17(4): 758–764.
STIERMAIER T, et al. Atrial arrhythmias in Takotsubo syndrome: is inflammation the missing link? Europace, 2018; 21(2): 184–185.
TEMPLIN C, et al. Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med, 2015; 373(10): 929–938.
ZALEWSKA-ADAMIEC M. GRACE score in the prognosis of patients with Takotsubo syndrome. J Interv Cardiol, 2020; 130(5): 429–436.