Keywords
Supplementation
Plants
Bioactive compounds
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Abstract
Objective: To conduct a review study on plant-based supplementation, highlighting its nutritional potential and the health benefits of bioactive compounds for the elderly population. Methods: This is an integrative review, with searches conducted in the PubMed, Lilacs, BVS, and Science Direct databases using the descriptors "Aging" AND "Herbal Plants Supplementation" AND "Bioactive Compounds," between the years 2021 and 2025. Results: One hundred articles were selected according to the inclusion criteria, and after careful reading, eight articles were eligible. The bioactive compounds flavonoids, polyphenols, terpenes, catechins, and curcuminoids emerge as the main secondary metabolites found in the cited supplements and were responsible for the antioxidant, anti- inflammatory, neuroprotective, and cytoprotective effects. Final considerations: The analyzed studies show that supplements containing plant extracts have significant therapeutic potential in the aging process, especially due to their antioxidant, anti-inflammatory, neuroprotective, and regenerative properties. Recent literature highlights the role of bioactive compounds of plant origin, especially flavonoids, polyphenols, tannins, terpenes, and other secondary metabolites, as promising agents in promoting longevity and overall health.
References
ABASS S, et al. Mecanismo de fitoconstituintes antibacterianos: uma revisão atualizada. Arch Microbiol. 2024, 206: 325.
ALAMGIR AN. Biotechnology, In Vitro Production of Natural Bioactive Compounds, Herbal Preparation, and Disease Management. In: Therapeutic use of medicinal plants and their extracts, 2024; 2: 585-664.
ARAÚJO M, et al. Química Verde e Otimização Multivariada na Extração de Compostos Fenólicos: O Potencial do NaDES em Matérias-Primas Alternativas para Extrudados Expandidos. Methods Protoc. 2025; p. 8: 82.
BAGABALDO P, et al. A suplementação de pectina melhora biomarcadores de obesidade e distúrbios lipídicos sanguíneos associados em camundongos hipercolesterolêmicos obesos. Curr. Res. Food Science, 2022; 5: 251–260.
BOCCHI M, FERNANDES R. Influência do açafrão (Curcuma longa) na melhoria dos parâmetros biológicos e comportamentais: uma revisão narrativa. Semina Cienc Biol Saude. 2022.
BRASIL. Direito à Alimentação Adequada. Secretaria de Direitos Humanos da Presidência da República. Brasília: Governo Federal; 2013.
CARLBERG C, et al. Modulating biological aging with food derived signals: a systems and precision nutrition perspective. Npj aging, 2025; 11 (76): 1-6.
CHAIYASIT P, et al. Discovering Skin Anti-Aging Potentials of the Most Abundant Flavone Phytochemical Compound Reported in Siam Violet Pearl. J Ethnopharmacol., 2025.
CHAACHOAY N, et al. Medicina herbal utilizada no tratamento de doenças humanas no Rif, norte de Marrocos. Arab J Sci Eng., 2022; 47: 131-53.
CHANDASEKARA A, KUMAR T. Roots and Tuber Crops as Functional Foods: A Review on Phytochemical Constituents and Their Potential Health Benefits. Int J Food Sci., 2016.
COSTA J, et al. Monoterpenes from Cinnamomum verum Bark and Their Antioxidant Potential. J Nat Prod., 2025.
DAMIANI C, et al. Aproveitamento de Resíduos Vegetais – Potenciais e Limitações. Palmas: EDUFT; 2020; 10-12.
FAO. Desperdício de alimentos custa ao mundo 750 bilhões de dólares, alerta novo relatório da FAO. Roma: FAO; 2013.
FRANZEM FL, et al. Uma revisão de seis plantas medicinais e aromáticas e seus benefícios para a saúde. Rev Fitos, 2025.
IZADI M, et al. Longevity and anti-aging effects of curcumin supplementation. Geroscience, 2024; 46 (3): 2933-2950.
KAGUEYAM S, et al. Extração Ecológica de Compostos Bioativos a partir de Resíduos Agroalimentares de Origem Vegetal: Avanços em Rumo à Valorização Sustentável. Plants, 2025; 14 (23): 3597.
KUMAR S, et al. Development of multi-herbal formulation with enhanced antimicrobial, antioxidant, cytotoxic, and antiaging properties. J Herb Med., 2024.
LIMA JUNIOR JR, et al. Medical Plants Use for Elderly: Knowledge of risks and benefits. Nursing, 2023.
MARIANE L, et al. Otimização do processo de extração verde de antioxidantes derivados do pomace- uva. Sustain Chem Pharm., 2024; 37: 101396.
MARTINS I, et al. The impact of Nutritional Supplementation on the Health, Physical Performance and Quality of Life of the Elderly: an Integrative Review. Lumen Virtus, 2025; 16 (49): 6475- 6490.
MENDES R, et al. Curcumin Supplementation and Cellular Longevity: A Natural Anti-Aging Strategy. Aging Cell., 2025.
MICHALAK M. Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. International Journal of Molecular Sciences, 2022; 23 (2): 585.
El- SAADONYA MT, et al. Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits a comprehensive review. Front. Immunol., 2025.
OLIVEIRA M, et al. Daidzein and Genistein: Natural Phytoestrogens with Cognitive Potential. Phytother Res., 2025.
QUINTERO- RINCÓN P, et al. Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): uma revisão dos avanços no conhecimento etnobotânico, composição fitoquímica e potencial farmacológico. Adv Tradit Med., 2025; 25: 331-51.
RAO V, POONIA A. Citrullus colocynthis (maçã amarga): compostos bioativos, perfil nutricional, propriedades nutracêuticas e potenciais aplicações alimentares: uma revisão. Food Prod Process and Nutr., 2023, 5: 4.
SILVA AM, et al. Uso de plantas medicinais durante a pandemia de COVID- 19 no Brasil. Sci Rep., 2023; 13: 16558.
SILVA J, et al. Neuroprotective effects of Ocimum americanum in aging models. J Ethnopharmacol., 2025.
SILVEIRA ES, et al. Bioproducts for the food industry: Physicochemical nutritional characterization, aromatic profile and nutritional labeling of flours of acerola (Malpighia emarginata) and umbu- cajá (Spondias sp.). Scietcia Plena, 2025; 21.
SIQUEIRA IR, et al. American Basil, Ocimum americanum, has Neuroprotective Properties in the Aging Process. Nutrients, 2025; 17 (14): 2368.
STRINGHETA P, et al. Tópicos Avançados de Pesquisa em Ciência e Tecnologia de Alimentos. Compostos Bioativos e seus efeitos a saúde. 2024; 5: 147-75.
SULTANA H, et al. Nutrientes, compostos bioativos e propriedades antinutricionais de genótipos de calêndula como alimento funcional promissor. Sci Rep., 2025; 15: 4867.
TANAKA K, et al. EGCG from Green Tea Enhances Caloric Restriction Benefits. Nutr Aging, 2025.
TEODORO AJ. Bioactive Compounds of Food: Their Role in the Prevention and Treatment of Diseases. Oxid Med Cell Longev. 2019.
WANG C, et al. A Utilização de Alto Valor e Sustentável do Poçace de Uva: Uma Revisão. Food Chem., 2024; 24.
YU F, et al. Cognitive effects of aerobic exercise in Alzheimer’s disease: a pilot randomized controlled trial. J Alzheimers Dis., 2021; 80 (1): 233-44.