Abstract
Objective: To conduct an integrative review of the literature on anatomical predilection, clinical manifestations, and diagnostic strategies related to breast cancer metastases in the head and neck region. Methods: The review was conducted in stages: formulation of the guiding question, search in the Medline/PubMed, Scopus, Web of Science, and PsycINFO databases, selection and extraction of data, critical analysis of the included studies, interpretation, and presentation of findings. Controlled descriptors in Health Sciences (DeCS) were used, combined by the Boolean operator “AND”. Results: Thirty-five studies were selected. It was observed that breast cancer metastases to the head and neck are rare events, as is supraclavicular involvement. However, among women, breast cancer stands out as the most frequent infraclavicular primary site associated with metastases in this region. Clinical manifestations may be nonspecific, contributing to late diagnoses and challenges in differentiating between primary and metastatic lesions. Final considerations: Professionals such as head and neck surgeons and dental surgeons should perform a detailed medical history and rigorous evaluation of clinical and radiographic findings. Signs such as paresthesia of the lip and chin deserve attention, as they may represent early manifestations of metastasis and aid in the differential diagnosis of oral lesions.
References
ADELSON RT, et al. Metastatic breast cancer of the oral cavity. American journal of otolaryngology, 2005; 26(4): 279-281.
AERDEN T, et al. Numb chin syndrome as a sign of mandibular metastasis: A case report. International journal of surgery case reports, 2017; 31: 68-71.
ANDO K., et al. Parotid gland metastasis of breast cancer: case report and review of the literature. Breast Care, 2011; 6(6): 471-473.
ASHABYAMIN M. R., et al. Breast ductal carcinoma metastasis to jaw bones: a case report. Novelty in Biomedicine, 2014; 2(1): 31-35.
BOHLI M, et al. Parotid gland metastasis from breast origin. J Clin Case Rep, 2018; 8(6): 1-3.
BRUCOLI M, et al. Zygomatic metastasis from breast cancer. Journal of Craniofacial Surgery, 2010; 21(6): 2012-2014.
CHAKRABORTY S, BANERJEE S. Understanding crosstalk of organ tropism, tumor microenvironment and noncoding RNAs in breast cancer metastasis. Mol Biol Rep, 2023; 50(11): 9601-9623.
CHU EC-P, et al. Metastatic breast cancer presenting as neck pain in a pregnant patient. Cureus, 2024; 16(1).
CMREČAK F, et al. Rare metastasis of breast cancer to mandible-a case report. Libri Oncologici: Croatian Journal of Oncology, 2018; 46(2-3): 121-124.
DANGORE-KHASBAGE SB, et al. Metastatic involvement of parotid from carcinoma of the breast—a case report. Oral and maxillofacial surgery, 2009; 13(1): 49-53.
DE ALMEIDA FREIRE N, et al. Oral and maxillofacial metastasis of male breast cancer: Report of a rare case and literature review. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2019; 127(1): e18-e22.
DE FREITAS FILHO SAJ, et al. Oral Metastasis of Breast Cancer: Rare Case Report. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2014; 117(2): e180.
DIB LL, et al. Breast metastasis around dental implants: a case report. Clinical implant dentistry and related research, 2007; 9(2): 112-115.
DODO M, et al. Metastasis in the mandibular condyle: a case report. Journal of Medical Case Reports, 2017; 11(1): 1-4.
ERICKSON HP, et al. Breast cancer metastasis to a mandibular extraction socket: a case report and discussion on clinical detection of metastasis to the oral cavity. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2014; 26(2): 262-267.
FIDLER IJ, POSTE G. The "seed and soil" hypothesis revisited. Lancet Oncol, 2008; 9(8): 808.
GONDIM DD, et al. The great mimicker: metastatic breast carcinoma to the head and neck with emphasis on unusual clinical and pathologic features. Head and Neck Pathology, 2017; 11(3): 306-313.
GONZÁLEZ-PÉREZ LM, et al. Mandibular metastases as first clinical sign of an occult male breast cancer. International journal of oral and maxillofacial surgery, 2012; 41(10): 1211-1214.
GUIMARÃES ALS, et al. Oral metastasis of breast carcinoma diagnosed by fine needle aspiration cytology. kidney, 2003; 10: 3.
HESS KR, et al. Metastatic patterns in adenocarcinoma. Cancer, 2006; 106(7): 1624-33.
JAIN S, et al. Buccal metastasis in a case of carcinoma breast: A rare case report with review of literature. International Journal of Surgery Case Reports, 2013; 4(4): 406-408.
KECHAGIAS N, et al. Metastasis of a ductal breast carcinoma to the buccal mucosa of the mandible with tooth involvement. Oral and maxillofacial surgery, 2012; 16(4): 377-381.
KHALILI M, et al. Metastatic breast carcinoma initially diagnosed as pulpal/periapical disease: a case report. Journal of endodontics, 2010; 36(5): 922-925.
KIRSCHNICK LB, et al. Metastasis to the oral and maxillofacial region: A systematic review. Oral Diseases, 2022; 28(1): 23-32.
KMEID M., et al. Metachronous, single metastasis to the parotid, from primary breast cancer: a case report and review of the literature. Case Reports in Oncological Medicine, 2016; 2016.
LONCAREVIC S, et al. Bilateral numb chin syndrome as a symptom of breast cancer metastasis in the mandible: a case report and discussion on the usefulness of cone-beam computed tomography to assess bone involvement in oral cancer. Oral radiology, 2016; 32(2): 136-142.
MELGAÇO-COSTA JLB, et al. Oral metastasis intraosseous mimicking periapical lesion: a case report. RGO-Revista Gaúcha de Odontologia, 2020; 68.
MIYAZAKI R, et al. Breast carcinoma metastasis to the cheek: a case report. Journal of Medical Case Reports, 2022; 16(1): 1-5.
MORRIS PR, et al. Male breast cancer with maxillofacial metastasis: case report. Journal of oral and maxillofacial surgery, 2001; 59(5): 578-580.
PANOSSIAN M., et al. Breast cancer metastatic to the mandible misdiagnosed as parotitis: report of a case. Journal of oral and maxillofacial surgery, 2009; 67(6): 1333-1337.
PISANI P, et al. Metastatic disease in head & neck oncology. Acta Otorhinolaryngol Ital, 2020; 40(SUPPL. 1): S1-S86.
PEINADO H, et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer, 2017;17(5): 302-317.
POULIAS E, et al. Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report. Journal of medical case reports, 2011; 5(1): 1-5.
POULOPOULOS AK, et al. Bilateral metastatic breast angiosarcoma to the mandibular gingiva: case report. Oral oncology, 2001; 37(2): 199-201.
RAM H, et al. Carcinoma of breast metastasising to mandible. Case Reports, 2015; bcr2014206571.
SAHOO NK, et al. Masticator space metastasis from a male breast carcinoma: A case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2013; 25(2): 160-163.
SAHOO S, et al. Breast carcinoma metastatic to ameloblastoma: a unique tumour‐to‐tumour metastasis. Histopathology, 2007; 50(6): 815-817.
SCIPIO JE, et al. Metastasis of breast carcinoma to mandibular gingiva. Oral oncology, 2001; 37(4): 393-396.
SELLINGER M, et al. Contralateral metastasis of parotid gland in advanced breast cancer with peripheral facial paralysis. Archives of gynecology and obstetrics, 2011; 284(6): 1557-1560.
SHAH MY, et al. Metastasis from breast cancer presenting as an epulis in the upper gingiva. Journal of oral and maxillofacial pathology: JOMFP, 2009; 13(1): 38.
SOUZA MT, et al. Revisão integrativa: o que é e como fazer. Einstein, 2010; 8(1): 102-106.
SUNG H, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 2021; 71(3):209-249.
SPIRITO F, et al. Challenging differential diagnosis of mandible angle metastasis from breast cancer. Case Reports in Dentistry, 2024; 2024(1): 2667323.
THORAWAT A., et al. Secondary Metastasis to the Mandible From Breast Carcinoma–A Rare Case Report. Journal of Clinical and Diagnostic Research: JCDR, 2015; 9(7): ZD25.
