Keywords
Liquid biopsy
HPV
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Abstract
Objective: To evaluate the predictive ability of a urine test in patients with HPV-induced vulvar, vaginal, and cervical pathologies. Methods: The study was prospective and descriptive, utilizing quantitative and qualitative analysis. Women with varying diagnoses were evaluated using biopsy and urine tests. Results: 87 women were selected and separated into four different groups: the control group (27,6%), the condyloma acuminata group (21,8%), the low-grade intraepithelial lesion group (21,8%), and the high-grade intraepithelial lesion group (28,7%). The results showed that the urinary test had a predictive value of 78,7% when compared to the anatomopathological standard, the biopsy. The high-grade intraepithelial lesion group showed perfect agreement with the urinary test results. The most frequent HPV genotypes identified were HPV16, followed by HPV6, 52, and 53. Conclusion: The urinary test proved valuable in HPV DNA investigation, especially in the high-grade intraepithelial lesions group. However, further research is necessary to expand the study, and additional strategies must be employed to enhance women's adherence.
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