Keywords
Manifestação bucal
Mucosa bucal
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Abstract
Objective: Analyze oral manifestations associated with individuals affected by dengue. Methods: Searches were performed in the Scientific Electronic Library Online (SciELO), National Library of Medicine (NIH/PubMed), and Virtual Health Library (BVS) databases between April 2024 and September 2025 by three independent researchers. The descriptors dengue, oral manifestation, and mouth mucosa were used, combined with the Boolean operators AND and OR. Results: A total of 53 studies were identified across the databases. After screening titles and abstracts and conducting full-text assessments according to the predefined inclusion and exclusion criteria, 8 studies were included in the review. Conclusions: Dengue virus infection may be associated with various oral manifestations, particularly spontaneous bleeding, petechiae, vesicles, bullae, plaques, and hemorrhagic crusts. Less frequent alterations, such as pseudomembranous candidiasis, transient lingual papillitis, and xerostomia, were also reported. The recognition of these manifestations by dental professionals may contribute to the early diagnosis of dengue and to the reduction of disease-related morbidity.
References
AHMED S, et al. The 2011 dengue hemorrhagic fever outbreak in Lahore - an account of clinical parameters and pattern of hemorrhagic complications. Journal of the College of Physicians and Surgeons Pakistan. 2013; 23(7): 463-467.
AVIV-REUVEN S, ROSENFELD A. Publication patterns’ changes due to the COVID-19 pandemic: a longitudinal and short-term scientometric analysis. Scientometrics. 2021; 126(8): 6761-6784.
ARAÚJO LP, et al. Oral manifestations of dengue virus infection: a scoping review for clinical dental practice. BMC Oral Health. 2025; 25(1): 138.
BYATNAL A, et al. Unusual yet isolated oral manifestations of persistent thrombocytopenia: A rare case report. Brazilian Journal of Oral Sciences. 2013; 12(1): 233-236.
BARAYAN RM, et al. An overview of oral candidiasis in immunocompromised pediatric patients: pathogenesis, diagnosis and management. Journal of Healthcare Sciences. 2024; 4(12): 971-976.
CONSELHO REGIONAL DE ODONTOLOGIA DE MINAS GERAIS. Manifestações bucais da dengue, zika e chikungunya: O CRO-MG te conta tudo sobre o assunto. 2024. Disponível em:
DONATO AJ, et al. Cellular and molecular biology of aging endothelial cells. Journal of Molecular and Cellular Cardiology. 2015; 89(Pt B): 122-135.
DREIZEN S, et al. Oral manifestations of leukemia. Journal of Oral Surgery. 1977; 35(12): 994-1000.
FARHI D, DUPIN N. Pathophysiology, diagnosis, and management of infectious mononucleosis. Clinical Microbiology Reviews. 2010; 23(4): 689-708.
FERNANDES CIR, et al. Uncommon oral manifestations of dengue viral infection. Brazilian Journal of Otorhinolaryngology. 2020; 86(1): 3-5.
FIOCRUZ. Doenças no portal Fiocruz - dengue. Rio de Janeiro: Fiocruz; 2025. Disponível em: https://fiocruz.br/taxonomia-geral-05-doencas/dengue. Acesso em: 20 jan. 2025.
GOVINDARAJ S, et al. Oral manifestations of dengue fever. Sahel Medical Journal. 2018; 21(4): 194.
GHOSH A, et al. Dengue Virus and the Host Immune System: A Battle of Immune Modulation, Response and Evasion. Pathogens. 2025; 14(11):1132.
HOU GL, HUANG JS, TSAI CC. Analysis of oral manifestations of leukemia: a retrospective study. Oral Surgery, Oral Medicine, Oral Pathology. 1997; 83(4): 452-456.
JELIA SC, et al. Predictors of hemorrhagic manifestations in dengue: a prospective observational study from the Hadoti region of Rajasthan. Journal of Acute Disease. 2023; 12(6): 226-232.
KITTIGUL L, et al. The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection. Journal of Clinical Virology. 2007; 39(2): 76-81.
KHAN S, et al. Acute gingival bleeding as a complication of dengue hemorrhagic fever. Journal of Indian Society of Periodontology. 2013; 17(4): 520-522
LIU Y, et al. Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023). Journal of Translational Medicine. 2024; 22(1): 818.
MALAVIGE GN, et al. Patterns of disease in Sri Lankan dengue patients. Archives of Disease in Childhood. 2006; 91(5): 396-400.
MARGRAF A, et al. Ontogeny of platelet function. Blood Advances. 2019; 3(4): 692-703.
MARTINA BE, KORAKA P, OSTERHAUS AD. Dengue virus pathogenesis: an integrated view. Clinical Microbiology Reviews. 2009; 22(4): 564-581.
MINISTÉRIO DA SAÚDE. Secretaria de Vigilância em Saúde. Dengue: diagnóstico e manejo clínico – adulto e criança. 4. ed. Brasília: Ministério da Saúde, 2013.
MINISTÉRIO DA SAÚDE. Secretaria de Vigilância em Saúde e Ambiente. Informe Semanal nº 17: Monitoramento das arboviroses transmitidas pelo Aedes aegypti – semanas epidemiológicas 01 a 23 de 2025. Brasília: Ministério da Saúde, 2025a.
MINISTÉRIO DA SAÚDE. Entenda como vai funcionar a primeira vacina contra a dengue com produção 100% nacional. 2025b. Disponível em: https://www.gov.br/saude/pt-br/assuntos/noticias/2025/novembro/entenda-como-vai-funcionar-a-primeira-vacina-contra-a-dengue-com-producao-100-nacional. Acesso em: 19 jan. 2025.
MITHRA R, et al. Oral Presentation in Dengue Hemorrhagic Fever: A Rare Entity. Journal of Natural Science, Biology and Medicine. 2013; 4(1): 264-267.
MORRISON J, et al. Innate immunity evasion by Dengue virus. Viruses. 2012; 4(3): 397-413.
MOUTSOPOULOS NM, KONKEL JE. Tissue-specific immunity at the oral mucosal barrier. Trends in Immunology. 2018; 39(4): 276-287.
MUTHENENI SR, et al. Dengue burden in India: recent trends and importance of climatic parameters. Emerging Microbes & Infections, 2017; 6(1): 1-10.
OLIVEIRA AA, et al. Manifestações orais de arboviroses com ênfase em dengue, zika e chikungunya: revisão de literatura. Archives of Health Investigation. 2021; 10(2): 323-328.
PATEL M. Oral cavity and Candida albicans: colonisation to the development of infection. Pathogens. 2022; 11(3): 335.
PISKIN S, et al. Oral findings in patients with idiopathic thrombocytopenic purpura. Journal of the American Academy of Dermatology. 2002; 46(6): 845-849.
PONTES FSC, et al. Severe oral manifestation of dengue viral infection: A rare clinical description. Quintessence International. 2014; 45(2): 151-156.
RAYNAUD M, et al. Impact of the COVID-19 pandemic on publication dynamics and non-COVID-19 research production. BMC Medical Research Methodology. 2021; 21(1): 255.
RICCABONI M, VERGINER L. The impact of the COVID-19 pandemic on scientific research in the life sciences. PLOS ONE. 2022; 17(2): e0263001.
SEALS DR, et al. You’re only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology. 2014; 29(4): 250-264.
SIMMONS CP, et al. Dengue. The New England Journal of Medicine. 2012; 366(15): 1423-1432.
THOMAS EA, et al. Cutaneous manifestations of dengue viral infection in Punjab (north India). International Journal of Dermatology. 2007; 46(7): 715-719.
WORLD HEALTH ORGANIZATION. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva: WHO; 2009.
WORLD HEALTH ORGANIZATION. Dengue - Global situation. 2024. Disponível em:
https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON518. Acesso em: 19 jan. 2025.
YAMAMOTO K. Oral manifestation like Forchheimer spots of dengue fever. The American Journal of Tropical Medicine and Hygiene. 2019; 101(4): 729.
ZOELLNER H, et al. Microvasculature in gingivitis and chronic periodontitis: disruption of vascular networks with protracted inflammation. Microscopy Research and Technique. 2002; 56(1): 15-31.