Keywords
Immune system diseases
Hematologic diseases
Breast implantation
Multiple myeloma
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Abstract
Objective: To describe a case of a male patient with siliconoma following industrial silicone injection, temporally associated with multiple myeloma. Case report: This is a 63-year-old male patient who illegally injected industrial silicone oil into the breasts, buttocks, and penis for aesthetic purposes and was subsequently diagnosed with Multiple Myeloma. The patient is currently undergoing chemotherapy and is awaiting completion of oncologic treatment to proceed with multidisciplinary follow-up involving urology, mastology, and plastic surgery for the management of aesthetic and structural complications resulting from silicone injection. During clinical investigation, the hypothesis of a possible correlation between exposure to industrial silicone and the development of the hematologic malignancy was considered, based on literature reports suggesting that prolonged silicone exposure may be associated with immunological and hematological alterations in humans. Final Considerations: Although a direct causal relationship between industrial silicone use and multiple myeloma cannot be established in this case, the coexistence of chronic foreign-body inflammation and hematologic neoplasia raises biological plausibility for such an association, highlighting the need for clinical surveillance in individuals undergoing clandestine aesthetic procedures and for future studies investigating the immunological and hematological effects of prolonged silicone exposure.
References
ARMENTEROS C, et al. Síndrome ASIA: prótesis mamarias y enfermedad de Still. Medicina (Buenos Aires), 2017; 77(5): 424-426.
BATISTA BN, et al. Relato de caso de linfoma anaplásico de células grandes associado a implante mamário em paciente brasileira. Revista Brasileira de Cirurgia Plástica, 2017; 32(3): 445-449.
DE-AZAMBUJA AP, et al. Linfoma anaplásico de células grandes associado a implantes mamários: um desafio diagnóstico. Revista Brasileira de Cirurgia Plástica, 2020; 35(1): 118-120.
DORNELAS MT, et al. Siliconomas. Revista Brasileira de Cirurgia Plástica, 2011; 26(1): 16-21.
GERK A, et al. Use of industrial liquid silicone: a scoping review. Acta Cirúrgica Brasileira, 2024; 39: e395624.
GHELLER RA, et al. BIA-ALCL e diagnóstico diferencial com linfoma anaplásico de grandes células sistêmico primário: relato de caso. Arquivos Catarinenses de Medicina, 2022; 51(1): 13-21.
GIACOMAZZO CM, et al. Síndrome autoimune induzida por adjuvantes desencadeada por implantes mamários de silicone: revisão sistemática. Revista Brasileira de Cirurgia Plástica, 2023; 37: 485-493.
MANJARRES-GUEVARA AE, et al. Consideraciones clínicas y desenlaces quirúrgicos del cáncer asociado a implante mamario: una enfermedad emergente de interés. Revista de la Facultad de Medicina Humana, 2023; 23(2): 130-137.
MEIRA AAM, et al. Abordagem reconstrutora após injeção de silicone líquido industrial nas mamas. Revista Brasileira de Cirurgia Plástica, 2019; 34(Supl 2): 62-64.
MISAD C, et al. Linfoma anaplásico de células grandes asociado a implantes mamarios diagnosticado mediante punción por aguja fina: caso clínico. Revista Médica de Chile, 2020; 148(8): 1207-1212.
MUSTIN DE, et al. Management of silicone granuloma: a systematic review. JAAD International, 2023; 11: 41-42.
PAIPILLA-SANDOVAL M, et al. Linfoma anaplásico de células gigantes asociado a implantes mamarios, una enfermedad desconocida. Iatreia, 2023; 36(2): 221-232.
PEPPE NETO AP, et al. Linfoma anaplásico de grandes células T associado ao uso de implantes (BIA-ALCL): relato de caso. Revista Brasileira de Cirurgia Plástica, 2024; 39(2): 1-5.
PEREIRA PC. Injeção de silicone industrial intramamário – aspectos mamográficos. Dr Pixel, 2016.
PICARD-AMI JR LA. Primer caso en Panamá de linfoma anaplásico de células grandes asociado a implantes mamarios (LACG-AIM). Cirugía Plástica Ibero-Latinoamericana, 2020; 46(3): 273-282.
PRADO A, GULER K. Prótesis mamarias texturizadas y linfoma anaplástico de células grandes. Revista de Cirugía, 2021; 73(4): 526-527.
REAL DSS, RESENDES BS. Linfoma anaplásico de grandes células relacionado ao implante mamário: revisão sistemática da literatura. Revista Brasileira de Cirurgia Plástica, 2019; 34: 531-538.
SÁNCHEZ CC, et al. Limitaciones diagnósticas de las determinaciones inmunohistoquímicas preoperatorias en el linfoma anaplásico de células grandes asociado a implante mamario (LACG-AIM). Cirugía Plástica Ibero-Latinoamericana, 2019; 45(3): 243-252.
SILVA LGS, et al. Série de casos de BIA-ALCL no Distrito Federal, Brasil. Revista Brasileira de Cirurgia Plástica, 2025; 40.
SILVEIRA LJH, et al. reast implant-associated anaplastic large cell lymphoma: a call for disease awareness. Hematology, Transfusion and Cell Therapy, 2023; 45: 124-126.
SILVERMAN S, et al. Silicone gel implants and monoclonal gammopathies: three cases of multiple myeloma and the prevalence of multiple myeloma and monoclonal gammopathy of undetermined significance. In: KRAMER JM e PASTERNAK JF (eds). Immunology of Silicones. Springer, 1996: 367-374.
TORRES PÉREZ A, et al. Linfoma anaplásico de células grandes e implantes mamarios: revisión sistemática de las casuísticas publicadas. Cirugía Plástica Ibero-Latinoamericana, 2020; 46(1): 25-36.
TORRES-RIVERO C, et al. Primer caso en México y América Latina de linfoma anaplásico de células gigantes en paciente con implantes mamarios. Cirugía Plástica Ibero-Latinoamericana, 2016; 42(2): 175-180.
UMAÑA ORDÓÑEZ M, et al. Linfoma anaplásico de células grandes asociado a implantes mamarios: cuatro casos diagnosticados en la provincia de Alicante, España. Cirugía Plástica Ibero-Latinoamericana, 2019; 45(3): 225-234.
VERA GARCÍA PJ, et al. Primer caso en la Región de Murcia (España) de linfoma anaplásico de células grandes asociado a implantes mamarios. Cirugía Plástica Ibero-Latinoamericana, 2019; 45(3): 235-242.
VOTTO R, GROTH A. Breast implant illness: onde estamos e para onde vamos? Revista Brasileira de Cirurgia Plástica, 2022; 37(1): 89-93.
WONG HC, et al. Paraneoplastic acquired ichthyosis as the first manifestation in breast implant-associated anaplastic large cell lymphoma. Anais Brasileiros de Dermatologia, 2024; 99(4): 621-624.