Abstract
Objective: To report a clinical case in which negative pressure wound therapy (NPWT) was used to treat an enterocutaneous fistula (ECF) caused by postoperative adhesions after appendectomy. Case details: A male patient with a history of appendectomy and previous laparotomy presented with acute obstructive abdomen and underwent another laparotomy for intestinal adhesiolysis. Shortly after discharge, he developed a surgical site infection and a difficult-to-control ECF. Considering the complexity of the condition and the need to reduce fistula output, NPWT was initiated. After device placement, there was a progressive decrease in output, marked improvement in inflammatory and infectious markers, clinical stabilization, and rapid diet advancement. The intervention also provided better protection of the surrounding skin and optimized the healing process. Final considerations: NPWT proved to be a safe, effective, and essential tool in this patient’s recovery, enabling shorter hospital stay, faster wound healing, and earlier return to daily activities, representing an important adjuvant therapeutic option in the management of ECFs.
References
AMIM BP, et al. Abordagens endoscópicas no tratamento de fístulas e deiscências gastrointestinais. International Journal of Health Management Review, 2021; 7(3): 1-8.
BADRASAWI MM, et al. Nutritional management of enterocutaneous fistula: a retrospective study at a Malaysian university medical center. Journal of Multidisciplinary Healthcare, 2014; 7: 161-170.
BLEIER JI, HEDRICK T. Metabolic support of the enterocutaneous fistula patient. Clinics in Colon and Rectal Surgery, 2010; 23(3): 180-189.
CHIARETTI M, et al. Enterocutaneous fistula management and clinical nutrition in sepsis of abdominal wall incisional hernia: tips, tricks and literature revision. Journal of Surgery, 2022; 7(10): 1525.
DENICU MM, et al. Therapeutic options in postoperative enterocutaneous fistula—A retrospective case series. Medicina (Kaunas), 2022; 58(5): 661.
ELLERY LL, SILVA JPR. Atualizações no Manejo de Fístulas Enterocutâneas e Enteroatmosféricas: revisão de literatura. Brazilian Journal of Implantology and Health Sciences, 2026; 8 (2): 429-442.
FANIZZA J, et al. Endoscopic Management of Post-Bariatric Surgery Complications: Diagnostic Work-Up and Innovative Approaches for Leak, Fistula, and Stricture Management. Diagnostics (Basel, Switzerland), 2026; 16(3): 431.
FUGLESTAD MA, MONSON JRT. Medical and surgical management of enterocutaneous fistula. Seminars in Colon and Rectal Surgery, 2023; 34(4): 100987.
GEFEN R, et al. Treatment of enterocutaneous fistula: a systematic review and meta-analysis. Tech Coloproctol. 2022; 26(11): 863–874.
GHIMIRE P. Management of enterocutaneous fistula: a review. Journal of the Nepal Medical Association, 2022; 60(245): 93-100.
Kantowski M, et al. Combined endoscopic-percutaneous treatment of upper gastrointestinal enterocutaneous fistula using vacuum therapy and resorbable plug insertion (Vac-Plug). Sci Rep., 2022; 12(1): 12221
KREIS ME, et al. Percutaneous endoscopic vacuum therapy for patients with postoperative enterocutaneous fistulas: a retrospective study. Tech Innov Gastrointest Endosc. 2026; 28(1): 250947.
LIN FY, HUANG PY. Systematic review of negative pressure wound therapy for head and neck wounds with fistulas. International Wound Journal, 2020; 17(1): 251-258.
LUGLIO G, et al. Combined surgical and negative pressure therapy to treat severely septic patient. Annali Italiani di Chirurgia, 2020; 91: 63-68.
MURPHY J, et al. Establishing a regional enterocutaneous fistula service: the Royal London Hospital experience. International Journal of Surgery, 2013; 11(10): 952-956.
NOORI IF. Postoperative enterocutaneous fistulas: management outcomes in 23 consecutive patients. Annals of Medicine and Surgery, 2021; 69: 102725.
PANAYI A, et al. Evidence based review of negative pressure wound therapy. World J Dermatol. 2017;6(1): 1-16
PEPE G, et al. Entero-cutaneous and entero-atmospheric fistulas: insights into management using negative pressure wound therapy. Journal of Clinical Medicine, 2024; 13(5): 1279.
TANG Q, et al. Nutritional support principles in patients with enterocutaneous fistula. Journal of the Nepal Medical Association, 2020; 58(230): 141-147.
WRIGHT H, et al. Topical management of enterocutaneous and enteroatmospheric fistulas: a systematic review. Wound Manag Prev. 2020; 66(4): 26–37.
