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Epidemiological profile and antimicrobial resistance of primary bloodstream infections associated with central venous catheters in the intensive care unit
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Keywords

Primary infection
Central venous cateter
Antimicrobial resistance

How to Cite

Epidemiological profile and antimicrobial resistance of primary bloodstream infections associated with central venous catheters in the intensive care unit. (2026). Electronic Journal Collection Health, 26(6), e23697. https://doi.org/10.25248/reas.e23697.2026

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Abstract

Objective: To analyze the incidence of primary bloodstream infections associated with central venous catheters in an Intensive Care Unit, identifying the microorganisms involved and their antimicrobial resistance profiles. Methods: This was a quantitative, retrospective, and longitudinal study conducted in an Intensive Care Unit, including a population of critically ill patients using central venous catheters. Data were collected over a three-year period from clinical records, epidemiological surveillance reports, and institutional microbiological results, using hospital databases and infection control systems as research instruments. Results: Variability in the incidence density of primary bloodstream infections was observed during the analyzed period, with episodes compatible with outbreaks and a high frequency of multidrug-resistant microorganisms. The findings highlight the relevance of these infections in the intensive care setting, associated with the complexity of critically ill patients and the increasing antimicrobial resistance, directly impacting patient safety and clinical outcomes. Conclusion: The main strength of the study lies in the longitudinal analysis of epidemiological and microbiological data, enabling a better understanding of the profile of primary bloodstream infections in the ICU. Limitations include the retrospective design and the reliance on secondary institutional records.

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References

ALP E, et al. The impact of infection control programs on hospital-acquired infections in intensive care units. International Journal of Infectious Diseases, 2011; 15(8): e543-e548.

BOUCHER HW, et al. Bad bugs, no drugs: no ESKAPE! Clinical Infectious Diseases, 2009; 48(1): 1-12.

CDC. National Healthcare Safety Network patient safety component manual. Centers for Disease Control and Prevention, 2022.

DELLINGER RP, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic

shock. Intensive Care Medicine, 2013; 39(2): 165-228.

LOGAN LK, WEINSTEIN RA. The epidemiology of carbapenem-resistant Enterobacteriaceae. Clinical Infectious Diseases, 2017; 65(7): 1026-1032.

MAGILL SS, et al. Changes in prevalence of health care–associated infections in U.S. hospitals. New England Journal of Medicine, 2018; 379(18): 1732-1744.

MARSCHALL J, et al. Strategies to prevent central line-associated bloodstream infections in acute care hospitals. Infection Control & Hospital Epidemiology, 2014; 35(7): 753-771.

MERMEL LA. Short-term peripheral venous catheter–related bloodstream infections: a systematic review. Clinical Infectious Diseases, 2017; 65(10): 1757-1762.

NIEDERMAN MS, et al. Guidelines for hospital-acquired and ventilator-associated pneumonia. Clinical Infectious Diseases, 2016; 63(5): e61-e111.

O'GRADY NP, et al. Guidelines for the prevention of intravascular catheter-related infections. Clinical Infectious Diseases, 2011; 52(9): e162-e193.

PAPPAS PG, et al. Clinical practice guideline for the management of candidiasis. Clinical Infectious Diseases, 2016; 62(4): e1-e50.

RICE LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens. Journal of Infectious Diseases, 2008; 197(8): 1079-1081.

ROSENTHAL VD, et al. International Nosocomial Infection Control Consortium report on device-associated infections in intensive care units. American Journal of Infection Control, 2020; 48(5): 553-562.

RUSSO TA e MARR CM. Hypervirulent Klebsiella pneumoniae. Clinical Microbiology Reviews, 2019; 32(3): e00001-19.

TACCONELLI E, et al. Discovery, research, and development of new antibiotics: the WHO priority list. The Lancet Infectious Diseases, 2018; 18(3): 318-327.

TUMBARELLO M, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase–producing strains. Clinical Infectious Diseases, 2012; 55(7): 943-950.

VINCENT JL, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA, 2009; 302(21): 2323-2329.

WEINSTEIN MP, et al. Clinical significance of positive blood cultures in hospitalized patients. Clinical Infectious Diseases, 2020; 71(6): 1561-1567.

WORLD HEALTH ORGANIZATION. Global report on infection prevention and control. Geneva: World Health Organization, 2022.

ZIMLICHMAN E, et al. Health care–associated infections: a meta-analysis of costs and financial impact. JAMA Internal Medicine, 2013; 173(22): 2039-2046.