Keywords
Epidemiology
Vulnerability
Amazon
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To analyze the epidemiological profile and the associated conditions of acute Chagas disease (ACD) in the Brazilian state of Pará, Brazilian Amazon. Methods: This is a descriptive, retrospective, historical series epidemiological study with a quantitative approach, conducted in the state of Pará. Secondary data from the Notification of Diseases Information System (SINAN), available on DATASUS, were used. The population included all confirmed cases from 2010 to 2024. Sociodemographic, clinical, and outcome variables were evaluated. The analysis was conducted using descriptive statistics, with the calculation of incidence and case fatality rate. Results: A total of 3,722 confirmed cases were recorded, with a growing trend over the years, especially from 2020 onward, peaking in 2023. The incidence followed this increase. Lethality showed annual variation, with deaths occurring throughout the period. Oral transmission stood out as the main route, often associated with the consumption of contaminated foods, such as açaí. A heterogeneous distribution was observed, with a higher concentration in areas of socio-environmental vulnerability. Conclusion: ACD remains relevant in Pará, with a growing trend. The need to strengthen surveillance is highlighted, despite the inherent limitations of using secondary data.
References
CARVALHO BF, et al. Fauna de triatomíneos e transmissão de Trypanosoma cruzi no estado do Pará, Amazônia brasileira: uma série histórica de 1977 a 2024. Parasites & Vectors, 2025; 18(1): 1-15.
ESPER HR, et al. Surtos agudos de doença de Chagas em Santarém, Pará, Brasil: diversidade genética de Trypanosoma cruzi e desfechos clínicos. Memórias do Instituto Oswaldo Cruz. 2025;120(1): e240089.
FINAMORE-ARAUJO P, et al. Detecção de Trypanosoma cruzi em amostras de polpa de açaí de áreas endêmicas na Amazônia brasileira. Food Microbiology, 2021; 96: 103721.
GBD 2023 CHAGAS DISEASE COLLABORATORS; RAISE STUDY GROUP. Carga global, regional e nacional da doença de Chagas, 1990-2023: uma análise sistemática para o Estudo da Carga Global de Doenças de 2023. The Lancet Infectious Diseases, 2025; 25(2): 178-195.
INTERNATIONAL COMMITTEE OF MEDICAL JOURNAL EDITORS (ICMJE). Requisitos uniformes para manuscritos submetidos a periódicos biomédicos. New England Journal of Medicine, 1997; 336(4): 309-315.
LABELLO BR, et al. Sobrevivência e infectividade do Trypanosoma cruzi na polpa do açaí: implicações para a transmissão oral da doença de Chagas, Acta Tropica, 2019; 198: 105106.
MALTA M, et al. Iniciativa STROBE: diretrizes para a elaboração de relatórios de estudos observacionais. Revista de Saúde Pública, 2010; 44(3): 559-565.
MOREIRA OC, et al. Real-Time PCR Assays for Quantification of Trypanosoma cruzi in Food Samples: A Tool for Surveillance of Oral Chagas Disease Outbreaks. In: T. cruzi Infection: Methods and Protocols, New York, NY: Springer US, 2025: 125-151.
OLIVEIRA AC, et al. Métodos de prevenção da doença de Chagas transmitida por alimentos. International Journal of Food Microbiology, 2019; 301: 34-40.
PÉREZ-GUERRERO EE, et al. Methodological and statistical considerations for cross-sectional, case– control, and cohort studies. Journal of clinical medicine, 2024, 13(14): 4005.
SALDANHA RF, et al. Microdatasus: pacote para download e pré-processamento de microdados do DATASUS. Cadernos de Saúde Pública, 2019; 35(9): e00032419.
SANTOS EF, et al. Doença de Chagas aguda no Brasil: tendências temporais e padrões espaciais de 2001 a 2022. Parasitology Research, 2020; 119(12): 4087-4096.
SANTOS VRCD, et al. Doença de Chagas aguda no estado do Pará, Amazônia brasileira: características clínicas, laboratoriais e epidemiológicas de 2013 a 2016. Revista da Sociedade Brasileira de Medicina Tropical, 2020; 53: e20190482.
SANTOS VRCD, et al. Vigilância epidemiológica da doença de Chagas aguda no estado do Pará: uma análise de 16 anos. Cadernos de Saúde Pública, 2018; 34(8): e00124717.
SILVA MROB, et al. Distribuição espacial e temporal da doença de Chagas aguda no Brasil, 2001-2022. Revista Brasileira de Epidemiologia, 2025; 28: e250015.
SMITH AK, et al. Conducting high-value secondary dataset analysis: an introductory guide. Journal of General Internal Medicine, 2011; 26(8): 920-929.
SMITH-DORIA S, et al. Acompanhamento sorológico de pacientes com doença de Chagas aguda na Amazônia brasileira: desafios na avaliação da cura. PLoS Neglected Tropical Diseases, 2025; 19(1): e0011234.
SOUSA AS, et al. Aspectos epidemiológicos e clínicos da doença de Chagas aguda na Amazônia brasileira. Revista da Sociedade Brasileira de Medicina Tropical, 2024; 57: e00234.
SOUSA AS, et al. Doença de Chagas. The Lancet. 2024; 403(10430): 2031-2045.
SOUSA DRT, et al. Perfil clínico e epidemiológico da doença de Chagas aguda no estado do Amazonas, Brasil, 2004-2022. Revista do Instituto de Medicina Tropical de São Paulo, 2023; 65: e45.
WILLIS LD. How to write the methods section of a research manuscript. Respiratory Care, 2023; 68(5): 1763-1770.
XAVIER SC, et al. Transmissão à distância do Trypanosoma cruzi: um novo padrão epidemiológico da doença de Chagas na região Amazônica. Memórias do Instituto Oswaldo Cruz, 2014; 109(8):1066- 1068.